FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028393412> ?p ?o ?g. }

• W2028393412 endingPage "138" @default.
• W2028393412 startingPage "131" @default.
• W2028393412 abstract "The effects of the non-selective β-adrenergic blocking agent pindolol upon central monoaminergic neurotransmission in rats were studied by means of in vivo biochemical methods. It was found that (−)-pindolol elicited a clearcut, selective, dose-dependent and stereospecific reduction of brain 5-HT synthesis rate. The synthesis reduction was not accompanied by any change in the tissue tryptophan levels and could not be prevented by depleting the monoamine stores by means of reserpine. Furthermore, in non-pretreated animals, (−)- but not (+)-pindolol (nor the β1- and β2-selective adrenoceptor antagonists metoprolol, betaxolol and ICI 118,551) decreased the 5-HIAA level and the 5-HIAA/5-HT ratio while neither enantiomer altered the concentrations of 5-HT or NA, or DA and its metabolites. It is suggested that these effects of (−)-pindolol may be due to direct stimulation of 5-HT receptors in the CNS. The action of the compound is discussed within the context of literature data indicating its ability to act as an antagonist of certain other aspects of 5-HT receptor activation. The possibility is considered that, in addition to its β-adrenergic properties. (−)-pindolol is a mixed agonist-antagonist at central 5-HT receptors." @default.
• W2028393412 created "2016-06-24" @default.
• W2028393412 creator A5010748930 @default.
• W2028393412 creator A5038932065 @default.
• W2028393412 date "1986-09-01" @default.
• W2028393412 modified "2023-10-14" @default.
• W2028393412 title "Is pindolol a mixed agonist-antagonist at central serotonin (5-HT) receptors?" @default.
• W2028393412 cites W1520817888 @default.
• W2028393412 cites W1591367141 @default.
• W2028393412 cites W1971547290 @default.
• W2028393412 cites W1976810415 @default.
• W2028393412 cites W1977895567 @default.
• W2028393412 cites W1978078464 @default.
• W2028393412 cites W1981064424 @default.
• W2028393412 cites W1995967723 @default.
• W2028393412 cites W1996029571 @default.
• W2028393412 cites W2002159489 @default.
• W2028393412 cites W2008913793 @default.
• W2028393412 cites W2017973347 @default.
• W2028393412 cites W2020768531 @default.
• W2028393412 cites W2023675599 @default.
• W2028393412 cites W2043205243 @default.
• W2028393412 cites W2045297840 @default.
• W2028393412 cites W2046005342 @default.
• W2028393412 cites W2047721620 @default.
• W2028393412 cites W2049537839 @default.
• W2028393412 cites W2061090773 @default.
• W2028393412 cites W2062899996 @default.
• W2028393412 cites W2065095084 @default.
• W2028393412 cites W2065664987 @default.
• W2028393412 cites W2066663898 @default.
• W2028393412 cites W2075256686 @default.
• W2028393412 cites W2079981362 @default.
• W2028393412 cites W2084297423 @default.
• W2028393412 cites W2084515342 @default.
• W2028393412 cites W2085181964 @default.
• W2028393412 cites W2086370837 @default.
• W2028393412 doi "https://doi.org/10.1016/0014-2999(86)90344-4" @default.
• W2028393412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2429847" @default.
• W2028393412 hasPublicationYear "1986" @default.
• W2028393412 type Work @default.
• W2028393412 sameAs 2028393412 @default.
• W2028393412 citedByCount "126" @default.
• W2028393412 countsByYear W20283934122013 @default.
• W2028393412 countsByYear W20283934122014 @default.
• W2028393412 countsByYear W20283934122016 @default.
• W2028393412 countsByYear W20283934122022 @default.
• W2028393412 crossrefType "journal-article" @default.
• W2028393412 hasAuthorship W2028393412A5010748930 @default.
• W2028393412 hasAuthorship W2028393412A5038932065 @default.
• W2028393412 hasConcept C126322002 @default.
• W2028393412 hasConcept C134018914 @default.
• W2028393412 hasConcept C169760540 @default.
• W2028393412 hasConcept C170493617 @default.
• W2028393412 hasConcept C185592680 @default.
• W2028393412 hasConcept C24998067 @default.
• W2028393412 hasConcept C2775864247 @default.
• W2028393412 hasConcept C2776885963 @default.
• W2028393412 hasConcept C2778073030 @default.
• W2028393412 hasConcept C2778499207 @default.
• W2028393412 hasConcept C2778527774 @default.
• W2028393412 hasConcept C2778938600 @default.
• W2028393412 hasConcept C2779938033 @default.
• W2028393412 hasConcept C53910766 @default.
• W2028393412 hasConcept C55493867 @default.
• W2028393412 hasConcept C58732023 @default.
• W2028393412 hasConcept C71924100 @default.
• W2028393412 hasConcept C86803240 @default.
• W2028393412 hasConcept C98274493 @default.
• W2028393412 hasConceptScore W2028393412C126322002 @default.
• W2028393412 hasConceptScore W2028393412C134018914 @default.
• W2028393412 hasConceptScore W2028393412C169760540 @default.
• W2028393412 hasConceptScore W2028393412C170493617 @default.
• W2028393412 hasConceptScore W2028393412C185592680 @default.
• W2028393412 hasConceptScore W2028393412C24998067 @default.
• W2028393412 hasConceptScore W2028393412C2775864247 @default.
• W2028393412 hasConceptScore W2028393412C2776885963 @default.
• W2028393412 hasConceptScore W2028393412C2778073030 @default.
• W2028393412 hasConceptScore W2028393412C2778499207 @default.
• W2028393412 hasConceptScore W2028393412C2778527774 @default.
• W2028393412 hasConceptScore W2028393412C2778938600 @default.
• W2028393412 hasConceptScore W2028393412C2779938033 @default.
• W2028393412 hasConceptScore W2028393412C53910766 @default.
• W2028393412 hasConceptScore W2028393412C55493867 @default.
• W2028393412 hasConceptScore W2028393412C58732023 @default.
• W2028393412 hasConceptScore W2028393412C71924100 @default.
• W2028393412 hasConceptScore W2028393412C86803240 @default.
• W2028393412 hasConceptScore W2028393412C98274493 @default.
• W2028393412 hasIssue "1-2" @default.
• W2028393412 hasLocation W20283934121 @default.
• W2028393412 hasLocation W20283934122 @default.
• W2028393412 hasOpenAccess W2028393412 @default.
• W2028393412 hasPrimaryLocation W20283934121 @default.
• W2028393412 hasRelatedWork W1981898266 @default.
• W2028393412 hasRelatedWork W1988938918 @default.
• W2028393412 hasRelatedWork W2012837477 @default.
• W2028393412 hasRelatedWork W2027411819 @default.
• W2028393412 hasRelatedWork W2055572014 @default.

• next