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- W2028393949 abstract "Abstract The previously reported high rates of acetylcholinesterase-catalysed hydrolysis of (±)-cis- and (±)-trans-2-dimethylaminocyclohexyl acetate methiodide (Baldridge, McCarville & Friess, 1955) have been re-investigated, the enantiomers of each geometrical isomer being used. The cis-enantiomers were inactive as substrates and the trans-enantiomers were hydrolysed at a very slow rate. These results are confirmed by studies on muscarinic tissue (guinea-pig ileum) in which only a weak stimulatory response was given with the trans-enantiomers (the cis-enantiomers were inactive). With each of the test systems used, the acetylcholine receptor showed an inversion of the “normal” configurational specificity although the enantiomer potency ratio was small, a phenomenon which has been observed in previous reports of inversion of configurational specificity." @default.
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- W2028393949 date "1970-03-01" @default.
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- W2028393949 title "1, 2-Disubstituted cyclohexanes as substrates of acetylcholinesterase and muscarinic agents. A re-investigation" @default.
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- W2028393949 doi "https://doi.org/10.1111/j.2042-7158.1970.tb08500.x" @default.
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