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• W2028395596 abstract "A beneficial effect of sigma (σ) agonists was previously described on several pharmacological models of learning impairments. We examined this effect in senescence-accelerated mice (SAM), which has been developed as a murine model of aging and cognitive dysfunction. SAMP8/Ta (P8, senescence-prone substrain), 10–12 months of age, showed significant impairments in mnemonic capacities, as compared to age-matched SAMR1/Ta controls (R1, senescence-resistant substrain). Tests included open-field behavior, spontaneous alternation performances in the Y-maze, step-down passive avoidance and place learning after repetitive training in a water-maze. Pretreatment with the σ agonists JO-1784 (igmesine) or PRE-084, at 0.1–3 mg/kg, s.c., significantly improved spontaneous alternation and passive avoidance performances in P8. JO-1784 or PRE-084, at 1 mg/kg, also improved place learning in the water-maze, and retention, in term of escape latency. The implication of σ sites was indicated by the lack of significant effect of JO-1783, the inactive enantiomer of JO-1784, and by the ability of BMY-14802 (5 mg/kg, i.p.) to antagonize the effects on passive avoidance of JO-1784 (0.5 mg/kg) or PRE-084 (1 mg/kg). Subchronic treatments with JO-1784 (0.5 mg/kg/day) or PRE-084 (1 mg/kg/day) during 10 days, allowed a significant improvement of learning during training in the water-maze, but retention was not significantly ameliorated. These results confirmed the interest of the SAM substrains as an experimental model for senile memory impairment and showed that σ agonists could improve the quality of learning, although they seem less effective on long-term memory retrieval upon chronic administration." @default.
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• W2028395596 date "1996-09-01" @default.
• W2028395596 modified "2023-09-26" @default.
• W2028395596 title "Beneficial effects of sigma agonists on the age-related learning impairment in the senescence-accelerated mouse (SAM)" @default.
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• W2028395596 doi "https://doi.org/10.1016/0006-8993(96)00565-3" @default.
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