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• W2028401452 abstract "Dysregulated cytokine production contributes to inflammatory and proliferative diseases. Therefore, inhibition of proinflammatory mediators such as TNF, IL-1, and IL-6 is of great clinical relevance. Actual strategies are aimed at preventing receptor activation through sequestration of the ligand. Here we describe the development of an inhibitor of murine IL-6 based on fused receptor fragments. Molecular modeling-guided analysis of the murine IL-6Rα revealed that mutations in the Ig-like domain D1 severely affect protein function, although D1 is not directly involved in the ligand-binding interface. The resulting single chain IL-6 inhibitor (mIL-6-RFP) consisting of domains D1–D3 of mgp130, a flexible linker, and domains D1–D3 of mIL-6Rα is a highly potent and specific IL-6 inhibitor. mIL-6-RFP will permit further characterization of the role of IL-6 in various disease models and could ultimately lead to anti-IL-6 therapy." @default.
• W2028401452 created "2016-06-24" @default.
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• W2028401452 date "2009-07-01" @default.
• W2028401452 modified "2023-09-23" @default.
• W2028401452 title "Development of an IL-6 Inhibitor Based on the Functional Analysis of Murine IL-6Rα1" @default.
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• W2028401452 doi "https://doi.org/10.1016/j.chembiol.2009.06.010" @default.
• W2028401452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19635415" @default.
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