FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028408087> ?p ?o ?g. }

• W2028408087 endingPage "52" @default.
• W2028408087 startingPage "43" @default.
• W2028408087 abstract "There is an evolving consensus that mild cognitive impairment (MCI) serves as a prodrome to Alzheimer's disease. Antioxidants and COX-2 (cyclo-oxygenase-2) inhibitors have also been reported to have beneficial effects against conditions of memory impairment. Newer drugs like cysteinyl leukotriene inhibitors have shown neuroprotective effect in animal models of ischemia. Thus, the present study purports to explore the potential role of montelukast (a cysteinyl leukotriene inhibitor) in concert with rofecoxib (COX-2 inhibitor) and caffeic acid (a 5-LOX inhibitor and potent antioxidant) against kainic acid induced cognitive dysfunction in rats. In the experimental protocol, kainic acid (0.4 μg/2 μl) in artificial cerebrospinal fluid (ACSF) was given intrahippocampally (CA3 region) to induce a condition similar to MCI. Memory performance was measured on days 10–14 and the locomotor activity was measured on days 1, 7 and 14. For estimation of biochemical, mitochondrial and histopathological parameters, animals were sacrificed on day 14, stored at − 80 °C and the estimation was done on the 15th day. The treatment groups consisting of montelukast (0.5 and 1 mg/kg), rofecoxib (5 and 10 mg/kg) and caffeic acid (5 and 10 mg/kg) showed significant improvement in memory performance, oxidative stress parameters and mitochondrial function as compared to that of control (kainic acid treated), however, combination of montelukast with rofecoxib showed significant improvement in their protective effect. Thus the present study emphasizes the positive modulation of cysteinyl leukotriene receptor inhibition on COX (cyclooxygenase) and LOX (lipoxygenase) pathways in the control of the neuroinflammation in kainic acid induced cognitive dysfunction in rats." @default.
• W2028408087 created "2016-06-24" @default.
• W2028408087 creator A5001755481 @default.
• W2028408087 creator A5031149703 @default.
• W2028408087 creator A5040979204 @default.
• W2028408087 creator A5047004036 @default.
• W2028408087 date "2012-11-01" @default.
• W2028408087 modified "2023-09-26" @default.
• W2028408087 title "Montelukast potentiates the protective effect of rofecoxib against kainic acid-induced cognitive dysfunction in rats" @default.
• W2028408087 cites W1017951118 @default.
• W2028408087 cites W116226516 @default.
• W2028408087 cites W1408977967 @default.
• W2028408087 cites W1506043065 @default.
• W2028408087 cites W1578257465 @default.
• W2028408087 cites W1588570886 @default.
• W2028408087 cites W1629086159 @default.
• W2028408087 cites W1825808183 @default.
• W2028408087 cites W1923027407 @default.
• W2028408087 cites W1969411592 @default.
• W2028408087 cites W1970169366 @default.
• W2028408087 cites W1971048984 @default.
• W2028408087 cites W1972272979 @default.
• W2028408087 cites W1973240518 @default.
• W2028408087 cites W1990802251 @default.
• W2028408087 cites W1993943341 @default.
• W2028408087 cites W1994493274 @default.
• W2028408087 cites W1998658483 @default.
• W2028408087 cites W2000606066 @default.
• W2028408087 cites W2001837071 @default.
• W2028408087 cites W2004525117 @default.
• W2028408087 cites W2006016281 @default.
• W2028408087 cites W2006370393 @default.
• W2028408087 cites W2007521424 @default.
• W2028408087 cites W2007991927 @default.
• W2028408087 cites W2011505796 @default.
• W2028408087 cites W2019434048 @default.
• W2028408087 cites W2021399938 @default.
• W2028408087 cites W2022016756 @default.
• W2028408087 cites W2026049346 @default.
• W2028408087 cites W2028407503 @default.
• W2028408087 cites W2030158939 @default.
• W2028408087 cites W2031651670 @default.
• W2028408087 cites W2031893098 @default.
• W2028408087 cites W2044521513 @default.
• W2028408087 cites W2048176284 @default.
• W2028408087 cites W2052627002 @default.
• W2028408087 cites W2058926287 @default.
• W2028408087 cites W2061253827 @default.
• W2028408087 cites W2071955212 @default.
• W2028408087 cites W2074551112 @default.
• W2028408087 cites W2077885883 @default.
• W2028408087 cites W2080015189 @default.
• W2028408087 cites W2081145676 @default.
• W2028408087 cites W2083098980 @default.
• W2028408087 cites W2089691650 @default.
• W2028408087 cites W2093141364 @default.
• W2028408087 cites W2093671206 @default.
• W2028408087 cites W2105925256 @default.
• W2028408087 cites W2106327430 @default.
• W2028408087 cites W2108176270 @default.
• W2028408087 cites W2146217163 @default.
• W2028408087 cites W2146567534 @default.
• W2028408087 cites W2146911942 @default.
• W2028408087 cites W2169473035 @default.
• W2028408087 cites W2171335844 @default.
• W2028408087 doi "https://doi.org/10.1016/j.pbb.2012.07.015" @default.
• W2028408087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22878042" @default.
• W2028408087 hasPublicationYear "2012" @default.
• W2028408087 type Work @default.
• W2028408087 sameAs 2028408087 @default.
• W2028408087 citedByCount "31" @default.
• W2028408087 countsByYear W20284080872013 @default.
• W2028408087 countsByYear W20284080872014 @default.
• W2028408087 countsByYear W20284080872015 @default.
• W2028408087 countsByYear W20284080872016 @default.
• W2028408087 countsByYear W20284080872017 @default.
• W2028408087 countsByYear W20284080872018 @default.
• W2028408087 countsByYear W20284080872019 @default.
• W2028408087 countsByYear W20284080872020 @default.
• W2028408087 countsByYear W20284080872021 @default.
• W2028408087 countsByYear W20284080872022 @default.
• W2028408087 countsByYear W20284080872023 @default.
• W2028408087 crossrefType "journal-article" @default.
• W2028408087 hasAuthorship W2028408087A5001755481 @default.
• W2028408087 hasAuthorship W2028408087A5031149703 @default.
• W2028408087 hasAuthorship W2028408087A5040979204 @default.
• W2028408087 hasAuthorship W2028408087A5047004036 @default.
• W2028408087 hasConcept C126322002 @default.
• W2028408087 hasConcept C134018914 @default.
• W2028408087 hasConcept C170493617 @default.
• W2028408087 hasConcept C181199279 @default.
• W2028408087 hasConcept C185592680 @default.
• W2028408087 hasConcept C25498285 @default.
• W2028408087 hasConcept C2776042228 @default.
• W2028408087 hasConcept C2776108384 @default.
• W2028408087 hasConcept C2776151105 @default.
• W2028408087 hasConcept C2776322731 @default.
• W2028408087 hasConcept C2776914184 @default.

• next