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- W2028410286 abstract "Besides his pioneering work in the development and use of fat emulsions in parenteral nutrition, Arvid Wretlind's interest also resided in protein and amino acid metabolism. He was among the first to demonstrate that in animals growth could be achieved by using synthetic amino acids instead of dietary protein. Here, amino acids not only serve as important building blocks for protein synthesis; their growthpromoting and anabolic role is also related to the topic discussed in this article, namely the regulation of cell function by the cellular hydration state. Within the last few years, it has become clear that cellular hydration is rather dynamic and can change within minutes under the influence of hormones, nutrient supply and oxidative stress. Most importantly, such a short-term modulation of cell volume within a narrow range, acts per se as a potent signal which modifies cellular metabolism and gene expression (for reviews see (13)). In fact, cell swelling due to osmotic water shifts into the cell acts as an anabolic signal. We are still at the beginning of the understanding of this novel and important mechanism of metabolic control. Alterations of cellular hydration under the influence of glutamine are at least one major mechanism underlying the anabolic effects of glutamine. Meanwhile evidence is accumulating that disturbances of cellular hydration may be important in the understanding of a variety of clinical conditions such as protein-catabolic states (4), cholestasis (5), viral infection (6) and hepatic encephalopathy (7). Only a few aspects will be adressed in this article. The interaction between cellular hydration and cell function was most extensively studied in liver cells, but evidence is increasing that modulation of cell function in response to alterations of cellular hydration is a general mechanism. Factors modulating cellular hydration" @default.
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- W2028410286 date "1995-02-01" @default.
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- W2028410286 title "Regulation of metabolism by changes in cellular hydration" @default.
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- W2028410286 doi "https://doi.org/10.1016/s0261-5614(06)80003-8" @default.
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