FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028421750> ?p ?o ?g. }

• W2028421750 endingPage "191" @default.
• W2028421750 startingPage "183" @default.
• W2028421750 abstract "Inflammation can activate self-reactive CD8+ T cells and induce autoimmunity. Here we show in a CD8+ T cell-mediated model of type 1 diabetes that CD4+CD25+ Treg cells prevent β cell destruction following localized inflammation in the islets of Langerhans. These Treg cells accumulate preferentially in the pancreatic lymph nodes and islets but not other lymph nodes or spleen. PLN-derived Treg cells are extremely potent; only 2 × 103 cells are needed to prevent diabetes development, and their capacity to regulate is dependent on TNF-related activation induced cytokine-receptor activator of NFκB signals. Indeed, blockade of this pathway results in decreased frequency of CD4+CD25+ Treg cells in the PLN, resulting in intra-islet differentiation of CD8+ T cells into CTLs and rapid progression to diabetes." @default.
• W2028421750 created "2016-06-24" @default.
• W2028421750 creator A5064443404 @default.
• W2028421750 creator A5071545328 @default.
• W2028421750 creator A5079411311 @default.
• W2028421750 date "2002-02-01" @default.
• W2028421750 modified "2023-10-15" @default.
• W2028421750 title "Pancreatic Lymph Node-Derived CD4+CD25+ Treg Cells" @default.
• W2028421750 cites W1511403203 @default.
• W2028421750 cites W1534645474 @default.
• W2028421750 cites W1650001464 @default.
• W2028421750 cites W1661544713 @default.
• W2028421750 cites W1963578378 @default.
• W2028421750 cites W1986639127 @default.
• W2028421750 cites W1988841542 @default.
• W2028421750 cites W1989527030 @default.
• W2028421750 cites W1992069433 @default.
• W2028421750 cites W1994001162 @default.
• W2028421750 cites W1995201985 @default.
• W2028421750 cites W2045932062 @default.
• W2028421750 cites W2046749316 @default.
• W2028421750 cites W2071756824 @default.
• W2028421750 cites W2073101332 @default.
• W2028421750 cites W2086848645 @default.
• W2028421750 cites W2094374305 @default.
• W2028421750 cites W2101230909 @default.
• W2028421750 cites W2101821738 @default.
• W2028421750 cites W2103188802 @default.
• W2028421750 cites W2114866206 @default.
• W2028421750 cites W2116525981 @default.
• W2028421750 cites W2124621398 @default.
• W2028421750 cites W2125311191 @default.
• W2028421750 cites W2130822830 @default.
• W2028421750 cites W2135947561 @default.
• W2028421750 cites W2137182923 @default.
• W2028421750 cites W2137473611 @default.
• W2028421750 cites W2137560059 @default.
• W2028421750 cites W2139191751 @default.
• W2028421750 cites W2143063298 @default.
• W2028421750 cites W2150361947 @default.
• W2028421750 cites W2159987448 @default.
• W2028421750 cites W2160306941 @default.
• W2028421750 cites W2163331597 @default.
• W2028421750 cites W2165664819 @default.
• W2028421750 cites W2169279497 @default.
• W2028421750 doi "https://doi.org/10.1016/s1074-7613(02)00279-0" @default.
• W2028421750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11869680" @default.
• W2028421750 hasPublicationYear "2002" @default.
• W2028421750 type Work @default.
• W2028421750 sameAs 2028421750 @default.
• W2028421750 citedByCount "302" @default.
• W2028421750 countsByYear W20284217502012 @default.
• W2028421750 countsByYear W20284217502013 @default.
• W2028421750 countsByYear W20284217502014 @default.
• W2028421750 countsByYear W20284217502015 @default.
• W2028421750 countsByYear W20284217502016 @default.
• W2028421750 countsByYear W20284217502017 @default.
• W2028421750 countsByYear W20284217502018 @default.
• W2028421750 countsByYear W20284217502019 @default.
• W2028421750 countsByYear W20284217502020 @default.
• W2028421750 countsByYear W20284217502021 @default.
• W2028421750 countsByYear W20284217502022 @default.
• W2028421750 countsByYear W20284217502023 @default.
• W2028421750 crossrefType "journal-article" @default.
• W2028421750 hasAuthorship W2028421750A5064443404 @default.
• W2028421750 hasAuthorship W2028421750A5071545328 @default.
• W2028421750 hasAuthorship W2028421750A5079411311 @default.
• W2028421750 hasBestOaLocation W20284217501 @default.
• W2028421750 hasConcept C134018914 @default.
• W2028421750 hasConcept C142724271 @default.
• W2028421750 hasConcept C154317977 @default.
• W2028421750 hasConcept C165220095 @default.
• W2028421750 hasConcept C167672396 @default.
• W2028421750 hasConcept C202751555 @default.
• W2028421750 hasConcept C203014093 @default.
• W2028421750 hasConcept C2776090121 @default.
• W2028421750 hasConcept C2776914184 @default.
• W2028421750 hasConcept C2779720271 @default.
• W2028421750 hasConcept C2779855799 @default.
• W2028421750 hasConcept C2780130043 @default.
• W2028421750 hasConcept C2780849966 @default.
• W2028421750 hasConcept C2780931953 @default.
• W2028421750 hasConcept C502942594 @default.
• W2028421750 hasConcept C55493867 @default.
• W2028421750 hasConcept C555293320 @default.
• W2028421750 hasConcept C71924100 @default.
• W2028421750 hasConcept C79484868 @default.
• W2028421750 hasConcept C86803240 @default.
• W2028421750 hasConcept C8891405 @default.
• W2028421750 hasConcept C95444343 @default.
• W2028421750 hasConceptScore W2028421750C134018914 @default.
• W2028421750 hasConceptScore W2028421750C142724271 @default.
• W2028421750 hasConceptScore W2028421750C154317977 @default.
• W2028421750 hasConceptScore W2028421750C165220095 @default.
• W2028421750 hasConceptScore W2028421750C167672396 @default.
• W2028421750 hasConceptScore W2028421750C202751555 @default.
• W2028421750 hasConceptScore W2028421750C203014093 @default.
• W2028421750 hasConceptScore W2028421750C2776090121 @default.

• next