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• W2028443325 abstract "Many important evolutionary adaptations originate in the modification of gene regulatory circuits to produce new gene activity phenotypes. How do evolving populations sift through an astronomical number of circuits to find circuits with new adaptive phenotypes? The answer may often involve phenotypic plasticity. Phenotypic plasticity allows a genotype to produce different - alternative - phenotypes after non-genetic perturbations that include gene expression noise, environmental change, or epigenetic modification. We here analyze a well-studied model of gene regulatory circuits. A circuit's genotype encodes the regulatory interactions among circuit genes, and its phenotype corresponds to a stable gene activity pattern the circuit forms. For this model, we study how genotypes are arranged in genotype space, where the distance between two genotypes reflects the number of regulatory mutations that set those genotypes apart. Specifically, we address whether this arrangement favors adaptive evolution mediated by plasticity. We find that plasticity facilitates the origin of genotypes that produce a new phenotype in response to non-genetic perturbations. We also find that selection can then stabilize the new phenotype genetically, allowing it to become a circuit's dominant gene expression phenotype. These are generic properties of the circuits we study here. Taken together, our observations suggest that phenotypic plasticity frequently facilitates the evolution of novel beneficial gene activity patterns in gene regulatory circuits." @default.
• W2028443325 created "2016-06-24" @default.
• W2028443325 creator A5005002059 @default.
• W2028443325 creator A5065785449 @default.
• W2028443325 creator A5079730045 @default.
• W2028443325 date "2011-01-06" @default.
• W2028443325 modified "2023-10-03" @default.
• W2028443325 title "Phenotypic plasticity can facilitate adaptive evolution in gene regulatory circuits" @default.
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• W2028443325 doi "https://doi.org/10.1186/1471-2148-11-5" @default.
• W2028443325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3024936" @default.
• W2028443325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21211007" @default.
• W2028443325 hasPublicationYear "2011" @default.
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