Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028448688> ?p ?o ?g. }
- W2028448688 endingPage "131" @default.
- W2028448688 startingPage "125" @default.
- W2028448688 abstract "Although the efficacy of fluvastatin (HMG-CoA reductase inhibitor) in the treatment of primary hypercholesterolemia is well documented, a wide interindividual variation treatment response has been observed. We have studied the possible role of the AvaII (exon 13), HincII (exon 12), and PvuII (intron 15) polymorphisms at the low-density lipoprotein receptor (LDLR) gene on lipid-lowering response in 55 patients (36 to 70 years old) with primary hypercholesterolemia treated with fluvastatin for 16 weeks. LDLR genotypes were determined by PCR-RFLP. The results indicate that the AvaII and PvuII polymorphisms influence the cholesterol-lowering response of the HMG-CoA reductase inhibitor Fluvastatin. Patients carrying A+A+ (AvaII) or P1P1 (PvuII) homozygous genotypes presented lower reduction in total cholesterol, LDL-C and apolipoprotein B levels after 16 weeks of treatment with fluvastatin, when compared to other genotypes (P <0.05). Our data also support the previous assumption that the AvaII, HincII, and PvuII polymorphisms of the LDLR gene are associated with variation of serum cholesterol levels. Therefore, the identification of the LDLR genetic profile may provide better prediction of a patient's clinical response to fluvastatin. J. Clin. Lab. Anal. 14:125–131, 2000. © 2000 Wiley-Liss, Inc." @default.
- W2028448688 created "2016-06-24" @default.
- W2028448688 creator A5000487991 @default.
- W2028448688 creator A5022094735 @default.
- W2028448688 creator A5061951316 @default.
- W2028448688 creator A5091669690 @default.
- W2028448688 date "2000-01-01" @default.
- W2028448688 modified "2023-10-15" @default.
- W2028448688 title "Lipid-lowering response of the HMG-CoA reductase inhibitor fluvastatin is influenced by polymorphisms in the low-density lipoprotein receptor gene in Brazilian patients with primary hypercholesterolemia" @default.
- W2028448688 cites W10657359 @default.
- W2028448688 cites W1587728243 @default.
- W2028448688 cites W1950122010 @default.
- W2028448688 cites W1965974276 @default.
- W2028448688 cites W1969431763 @default.
- W2028448688 cites W1993249061 @default.
- W2028448688 cites W1997005762 @default.
- W2028448688 cites W2006610663 @default.
- W2028448688 cites W2008936746 @default.
- W2028448688 cites W2013024222 @default.
- W2028448688 cites W2014556439 @default.
- W2028448688 cites W2017602185 @default.
- W2028448688 cites W2018453565 @default.
- W2028448688 cites W2022501898 @default.
- W2028448688 cites W2025597011 @default.
- W2028448688 cites W2026924990 @default.
- W2028448688 cites W2029833995 @default.
- W2028448688 cites W2030617406 @default.
- W2028448688 cites W2031963160 @default.
- W2028448688 cites W2033226747 @default.
- W2028448688 cites W2034464717 @default.
- W2028448688 cites W2051861242 @default.
- W2028448688 cites W2057674977 @default.
- W2028448688 cites W2058239917 @default.
- W2028448688 cites W2061694970 @default.
- W2028448688 cites W2069974089 @default.
- W2028448688 cites W2077901889 @default.
- W2028448688 cites W2079920718 @default.
- W2028448688 cites W2084744450 @default.
- W2028448688 cites W2086644198 @default.
- W2028448688 cites W2089747265 @default.
- W2028448688 cites W2097412489 @default.
- W2028448688 cites W2105187058 @default.
- W2028448688 cites W2106543746 @default.
- W2028448688 cites W2109455905 @default.
- W2028448688 cites W2114126984 @default.
- W2028448688 cites W2116222603 @default.
- W2028448688 cites W2116404316 @default.
- W2028448688 cites W2118310760 @default.
- W2028448688 cites W2126615300 @default.
- W2028448688 cites W2154774609 @default.
- W2028448688 cites W2165520631 @default.
- W2028448688 cites W2168885003 @default.
- W2028448688 cites W2218787476 @default.
- W2028448688 cites W2950135326 @default.
- W2028448688 cites W4245512005 @default.
- W2028448688 cites W4296883165 @default.
- W2028448688 doi "https://doi.org/10.1002/(sici)1098-2825(2000)14:3<125::aid-jcla7>3.0.co;2-s" @default.
- W2028448688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6807834" @default.
- W2028448688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10797611" @default.
- W2028448688 hasPublicationYear "2000" @default.
- W2028448688 type Work @default.
- W2028448688 sameAs 2028448688 @default.
- W2028448688 citedByCount "42" @default.
- W2028448688 countsByYear W20284486882012 @default.
- W2028448688 countsByYear W20284486882013 @default.
- W2028448688 countsByYear W20284486882014 @default.
- W2028448688 countsByYear W20284486882015 @default.
- W2028448688 countsByYear W20284486882016 @default.
- W2028448688 countsByYear W20284486882017 @default.
- W2028448688 countsByYear W20284486882018 @default.
- W2028448688 countsByYear W20284486882019 @default.
- W2028448688 countsByYear W20284486882021 @default.
- W2028448688 crossrefType "journal-article" @default.
- W2028448688 hasAuthorship W2028448688A5000487991 @default.
- W2028448688 hasAuthorship W2028448688A5022094735 @default.
- W2028448688 hasAuthorship W2028448688A5061951316 @default.
- W2028448688 hasAuthorship W2028448688A5091669690 @default.
- W2028448688 hasBestOaLocation W20284486882 @default.
- W2028448688 hasConcept C104317684 @default.
- W2028448688 hasConcept C104950815 @default.
- W2028448688 hasConcept C126322002 @default.
- W2028448688 hasConcept C134018914 @default.
- W2028448688 hasConcept C134651460 @default.
- W2028448688 hasConcept C135763542 @default.
- W2028448688 hasConcept C181199279 @default.
- W2028448688 hasConcept C2776329913 @default.
- W2028448688 hasConcept C2777320049 @default.
- W2028448688 hasConcept C2778163477 @default.
- W2028448688 hasConcept C2778417548 @default.
- W2028448688 hasConcept C2779120738 @default.
- W2028448688 hasConcept C2780072125 @default.
- W2028448688 hasConcept C43554185 @default.
- W2028448688 hasConcept C54355233 @default.
- W2028448688 hasConcept C55493867 @default.
- W2028448688 hasConcept C62746215 @default.
- W2028448688 hasConcept C71924100 @default.
- W2028448688 hasConcept C86803240 @default.
- W2028448688 hasConceptScore W2028448688C104317684 @default.