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• W2028449364 abstract "1. The repetitive application of morphine gradually induced a contracture in the isolated guinea pig ileum. 2. The optimum conditions for induction of the contracture were as follows: the concentration, incubation time and washout time of morphine were 1 or 10 μM, 2 and 3 min, respectively. 3. Preincubation with naloxone or TTX blocked this morphine-induced contracture. 4. Among twitch-inhibiting drugs, only clonidine induced a contracture similar to that induced by morphine, while tetrodotoxin (TTX) and adenosine did not. 5. The contracture was also observed in the longitudinal muscle-myenteric plexus preparations. 6. These findings indicate that morphine has a dual inhibitory and excitatory action on the guinea pig ileum and that its repetitive application preferentially diminish the inhibitory one." @default.
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• W2028449364 date "1992-05-01" @default.
• W2028449364 modified "2023-09-27" @default.
• W2028449364 title "Contractile response of guinea pig ileum by repetitive application of morphine" @default.
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• W2028449364 doi "https://doi.org/10.1016/0306-3623(92)90100-x" @default.
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