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- W2028450449 abstract "Administration of a therapeutic antibody can lead to an anti-antibody response (AAR). Much effort has been applied to engineering antibodies with as little as possible non-human structure to minimize such responses. Here, we review reported AAR to murine, mouse-human chimeric, and humanized antibodies. Replacement of mouse immunoglobulin constant regions with human ones effects the largest immunogenicity reduction. Humanization of variable domains effects a further decrease." @default.
- W2028450449 created "2016-06-24" @default.
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- W2028450449 date "2005-05-01" @default.
- W2028450449 modified "2023-10-14" @default.
- W2028450449 title "Immunogenicity of engineered antibodies" @default.
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- W2028450449 doi "https://doi.org/10.1016/j.ymeth.2005.01.001" @default.
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