FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028455575> ?p ?o ?g. }

• W2028455575 endingPage "349" @default.
• W2028455575 startingPage "339" @default.
• W2028455575 abstract "Background aims Cirrhosis, end-stage liver disease, is caused by different mechanisms of injury, associated with persistent inflammation. Galectin-3 is an important regulator of fibrosis that links chronic inflammation to fibrogenesis. We investigated the role of bone marrow cell (BMC) transplantation in chronic inflammation and hepatic fibrosis. Methods Liver cirrhosis was induced by administration of carbon tetrachloride and ethanol to wild-type C57BL/6 or bone marrow chimeric mice. Bone marrow chimeras were generated by lethal irradiation and transplantation with BMC obtained from green fluorescent protein (GFP+ )donors. Wild-type cirrhotic mice were transplanted with BMC without irradiation. Livers from chimeras and cirrhotic transplanted mice were obtained for evaluation of inflammation, fibrosis and regulatory factors [galectin-3, matrix metallopeptidase (MMP)-9, tissue inhibitor of metalloproteinase (TIMP)-1 and transforming growth factor (TGF)-β]. Results The development of cirrhosis was associated with increased expression of galectin-3 by F4/80+ cells and intense migration of BMC to the liver. Furthermore, when transplanted after the establishment of cirrhosis, BMC also migrated to the liver and localized within the fibrous septa. Two months after BMC therapy, cirrhotic mice had a significant reduction in liver fibrosis and expression of type I collagen. We did not find any difference in levels of TGF-β, TIMP-1 and MMP-9 between saline and BMC groups. However, the numbers of inflammatory cells, phagocytes and galectin-3+ cells were markedly lower in the livers of cirrhotic mice treated with BMC. Conclusions Our results demonstrate an important role for BMC in the regulation of liver fibrosis and that transplantation of BMC can accelerate fibrosis regression through modulatory mechanisms." @default.
• W2028455575 created "2016-06-24" @default.
• W2028455575 creator A5035535163 @default.
• W2028455575 creator A5051741247 @default.
• W2028455575 creator A5062192896 @default.
• W2028455575 creator A5064970697 @default.
• W2028455575 creator A5068387163 @default.
• W2028455575 creator A5068756156 @default.
• W2028455575 creator A5077741830 @default.
• W2028455575 creator A5087697204 @default.
• W2028455575 creator A5019274221 @default.
• W2028455575 date "2012-03-01" @default.
• W2028455575 modified "2023-10-14" @default.
• W2028455575 title "Reduction of galectin-3 expression and liver fibrosis after cell therapy in a mouse model of cirrhosis" @default.
• W2028455575 cites W1542326554 @default.
• W2028455575 cites W1547216586 @default.
• W2028455575 cites W1973278012 @default.
• W2028455575 cites W1974445411 @default.
• W2028455575 cites W1975373424 @default.
• W2028455575 cites W1982195551 @default.
• W2028455575 cites W1988358491 @default.
• W2028455575 cites W1995201433 @default.
• W2028455575 cites W2001967286 @default.
• W2028455575 cites W2002391829 @default.
• W2028455575 cites W2002897565 @default.
• W2028455575 cites W2005809144 @default.
• W2028455575 cites W2011508078 @default.
• W2028455575 cites W2012962601 @default.
• W2028455575 cites W2023299094 @default.
• W2028455575 cites W2025875442 @default.
• W2028455575 cites W2032639324 @default.
• W2028455575 cites W2040041350 @default.
• W2028455575 cites W2063161135 @default.
• W2028455575 cites W2069317280 @default.
• W2028455575 cites W2074246682 @default.
• W2028455575 cites W2085806058 @default.
• W2028455575 cites W2089154676 @default.
• W2028455575 cites W2090158969 @default.
• W2028455575 cites W2090387612 @default.
• W2028455575 cites W2096227000 @default.
• W2028455575 cites W2108969965 @default.
• W2028455575 cites W2115335074 @default.
• W2028455575 cites W2116500923 @default.
• W2028455575 cites W2116582289 @default.
• W2028455575 cites W2133860937 @default.
• W2028455575 cites W2150310611 @default.
• W2028455575 cites W2400292276 @default.
• W2028455575 cites W4212985336 @default.
• W2028455575 cites W4244051200 @default.
• W2028455575 cites W4250007760 @default.
• W2028455575 cites W4255712601 @default.
• W2028455575 doi "https://doi.org/10.3109/14653249.2011.637668" @default.
• W2028455575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22149185" @default.
• W2028455575 hasPublicationYear "2012" @default.
• W2028455575 type Work @default.
• W2028455575 sameAs 2028455575 @default.
• W2028455575 citedByCount "24" @default.
• W2028455575 countsByYear W20284555752012 @default.
• W2028455575 countsByYear W20284555752013 @default.
• W2028455575 countsByYear W20284555752014 @default.
• W2028455575 countsByYear W20284555752015 @default.
• W2028455575 countsByYear W20284555752016 @default.
• W2028455575 countsByYear W20284555752017 @default.
• W2028455575 countsByYear W20284555752018 @default.
• W2028455575 countsByYear W20284555752019 @default.
• W2028455575 countsByYear W20284555752020 @default.
• W2028455575 countsByYear W20284555752023 @default.
• W2028455575 crossrefType "journal-article" @default.
• W2028455575 hasAuthorship W2028455575A5019274221 @default.
• W2028455575 hasAuthorship W2028455575A5035535163 @default.
• W2028455575 hasAuthorship W2028455575A5051741247 @default.
• W2028455575 hasAuthorship W2028455575A5062192896 @default.
• W2028455575 hasAuthorship W2028455575A5064970697 @default.
• W2028455575 hasAuthorship W2028455575A5068387163 @default.
• W2028455575 hasAuthorship W2028455575A5068756156 @default.
• W2028455575 hasAuthorship W2028455575A5077741830 @default.
• W2028455575 hasAuthorship W2028455575A5087697204 @default.
• W2028455575 hasBestOaLocation W20284555752 @default.
• W2028455575 hasConcept C126322002 @default.
• W2028455575 hasConcept C142724271 @default.
• W2028455575 hasConcept C203014093 @default.
• W2028455575 hasConcept C2776914184 @default.
• W2028455575 hasConcept C2777214474 @default.
• W2028455575 hasConcept C2780007613 @default.
• W2028455575 hasConcept C2780559512 @default.
• W2028455575 hasConcept C2911091166 @default.
• W2028455575 hasConcept C71924100 @default.
• W2028455575 hasConceptScore W2028455575C126322002 @default.
• W2028455575 hasConceptScore W2028455575C142724271 @default.
• W2028455575 hasConceptScore W2028455575C203014093 @default.
• W2028455575 hasConceptScore W2028455575C2776914184 @default.
• W2028455575 hasConceptScore W2028455575C2777214474 @default.
• W2028455575 hasConceptScore W2028455575C2780007613 @default.
• W2028455575 hasConceptScore W2028455575C2780559512 @default.
• W2028455575 hasConceptScore W2028455575C2911091166 @default.
• W2028455575 hasConceptScore W2028455575C71924100 @default.
• W2028455575 hasIssue "3" @default.
• W2028455575 hasLocation W20284555751 @default.

• next