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• W2028459720 abstract "The steady-state hydro-electrodynamic model of Weinbaum & Caro (1976) for the vesicular transport of macromolecules across endothelial cell layers is extended to unsteady quasi one-dimensional vesicle diffusion and applied to existing time-dependent vesicle labelling studies. The model accounts for the spatially varying hydrodynamic and van der Waals force interaction between the vesicle and the boundary plasmalemma membranes of the endothelial cell. The present study also shows how Rubin's (1977) combined diffusion-reaction kinetics model for steady state permeability can be generalized to include an arbitrary spatial variation of the diffusion coefficient for a variable hydrodynamic resistance law in the cell interior. Approximate time-dependent solutions, valid for all times, are obtained using a novel integral solution technique for a multilayered media with variable diffusivity. Dimensionless time-dependent concentration profiles and flux ratios and dimensionless steady state permeability coefficients are generated independent of the cytoplasmic viscosity. When the time-dependent tracer data of Casley-Smith and Chin (1971) is used, the cytoplasmic viscosity is estimated to be 8·95 P." @default.
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• W2028459720 date "1980-07-01" @default.
• W2028459720 modified "2023-09-27" @default.
• W2028459720 title "Time dependent theory for vesicular transport across vascular endothelium" @default.
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• W2028459720 doi "https://doi.org/10.1016/0022-5193(80)90278-7" @default.
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