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- W2028481520 abstract "A number of gatifloxacin analogues containing a nitroaryl-1,3,4-thiadiazole moiety attached to the piperazine ring at C-7 position were prepared and evaluated as antibacterial agents against a panel of Gram-positive and Gram-negative bacteria. Among synthesized compounds, nitrofuran analog 6a exhibited more potent inhibitory activity against Gram-positive bacteria including Staphylococcus epidermidis (MIC = 0.0078 μg/mL), Bacillus subtilis (MIC = 0.0039 μg/mL), Enterococcus faecalis (MIC = 0.125 μg/mL) and Micrococcus luteus (MIC = 0.125 μg/mL), with respect to other synthesized compounds and reference drug gatifloxacin. The target compounds were also assessed for their cytotoxic activity against normal mouse fibroblast (NIH/3T3) cells using MTT assay. The results indicated that these compounds exhibit antibacterial activity at non-cytotoxic concentrations." @default.
- W2028481520 created "2016-06-24" @default.
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- W2028481520 date "2008-10-01" @default.
- W2028481520 modified "2023-10-05" @default.
- W2028481520 title "A signal transduction cascade from defense signal response to taxoid biosynthesis by elicitation of a novel synthetic benzothiadiazole in Taxus chinensis" @default.
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- W2028481520 doi "https://doi.org/10.1016/j.jbiotec.2008.07.328" @default.
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