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- W2028481572 abstract "An efficient solid-phase synthesis of 3,1-benzoxazine-4-ones is described. Immobilized amino acid based functionalized urea derivatives 2 undergo a high yielding heterocyclization under mild conditions in presence of coupling reagents (DIC, TsCl/Py, or Ac2O) to afford 3,1-benzoxazine-4-ones 6. The method offers broad scope for structural and chemical diversity, and is amenable for combinatorial synthesis of 3,1-benzoxazine-4-ones libraries with potential for discovery of novel serine protease inhibitors. Copyright 1998 John Wiley & Sons, Inc." @default.
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- W2028481572 date "1998-01-01" @default.
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- W2028481572 title "Combinatorial approaches to harmacophoric heterocycles: A solid-phase synthesis of 3,1-benzoxazine-4-ones" @default.
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- W2028481572 doi "https://doi.org/10.1002/(sici)1097-0290(199824)61:1<13::aid-bit5>3.0.co;2-1" @default.
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