FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028483312> ?p ?o ?g. }

• W2028483312 endingPage "9890" @default.
• W2028483312 startingPage "9882" @default.
• W2028483312 abstract "RSC, an essential chromatin remodeling complex in budding yeast, is involved in a variety of biological processes including transcription, recombination, repair, and replication. How RSC participates in such diverse processes is not fully understood. In vitro, RSC uses ATP to carry out several seemingly distinct reactions: it repositions nucleosomes, transfers H2A/H2B dimers between nucleosomes, and transfers histone octamers between pieces of DNA. This raises the intriguing mechanistic question of how this molecular machine can use a single ATPase subunit to create these varied products. Here, we use a FRET-based approach to kinetically order the products of the RSC reaction. Surprisingly, transfer of H2A/H2B dimers and histone octamers is initiated on a time scale of seconds when assayed by FRET, but formation of stable nucleosomal products occurs on a time scale of minutes when assayed by native gel. These results suggest a model in which RSC action rapidly generates an unstable encounter intermediate that contains the two exchange substrates in close proximity. This intermediate then collapses more slowly to form the stable transfer products seen on native gels. The rapid, biologically relevant time scale on which the transfer products are generated implies that such products can play key roles in vivo." @default.
• W2028483312 created "2016-06-24" @default.
• W2028483312 creator A5017792842 @default.
• W2028483312 creator A5047570506 @default.
• W2028483312 date "2010-10-25" @default.
• W2028483312 modified "2023-09-27" @default.
• W2028483312 title "The ATP-Dependent Remodeler RSC Transfers Histone Dimers and Octamers through the Rapid Formation of an Unstable Encounter Intermediate" @default.
• W2028483312 cites W1571482483 @default.
• W2028483312 cites W1587316578 @default.
• W2028483312 cites W1871617923 @default.
• W2028483312 cites W189575608 @default.
• W2028483312 cites W1968177936 @default.
• W2028483312 cites W1979668925 @default.
• W2028483312 cites W1982956209 @default.
• W2028483312 cites W1996363609 @default.
• W2028483312 cites W1999201519 @default.
• W2028483312 cites W2020582422 @default.
• W2028483312 cites W2030542066 @default.
• W2028483312 cites W2044385397 @default.
• W2028483312 cites W2050156039 @default.
• W2028483312 cites W2058412239 @default.
• W2028483312 cites W2059528721 @default.
• W2028483312 cites W2065123158 @default.
• W2028483312 cites W2068994422 @default.
• W2028483312 cites W2074097219 @default.
• W2028483312 cites W2075430280 @default.
• W2028483312 cites W2077846163 @default.
• W2028483312 cites W2083679421 @default.
• W2028483312 cites W2089456111 @default.
• W2028483312 cites W2100239410 @default.
• W2028483312 cites W2106363935 @default.
• W2028483312 cites W2139548989 @default.
• W2028483312 cites W2141991853 @default.
• W2028483312 cites W2147793191 @default.
• W2028483312 cites W2147808841 @default.
• W2028483312 cites W2165812194 @default.
• W2028483312 doi "https://doi.org/10.1021/bi101491u" @default.
• W2028483312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2976819" @default.
• W2028483312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20853842" @default.
• W2028483312 hasPublicationYear "2010" @default.
• W2028483312 type Work @default.
• W2028483312 sameAs 2028483312 @default.
• W2028483312 citedByCount "25" @default.
• W2028483312 countsByYear W20284833122012 @default.
• W2028483312 countsByYear W20284833122014 @default.
• W2028483312 countsByYear W20284833122015 @default.
• W2028483312 countsByYear W20284833122016 @default.
• W2028483312 countsByYear W20284833122017 @default.
• W2028483312 countsByYear W20284833122019 @default.
• W2028483312 countsByYear W20284833122020 @default.
• W2028483312 countsByYear W20284833122021 @default.
• W2028483312 countsByYear W20284833122022 @default.
• W2028483312 crossrefType "journal-article" @default.
• W2028483312 hasAuthorship W2028483312A5017792842 @default.
• W2028483312 hasAuthorship W2028483312A5047570506 @default.
• W2028483312 hasBestOaLocation W20284833122 @default.
• W2028483312 hasConcept C104292427 @default.
• W2028483312 hasConcept C104317684 @default.
• W2028483312 hasConcept C121332964 @default.
• W2028483312 hasConcept C12554922 @default.
• W2028483312 hasConcept C14519417 @default.
• W2028483312 hasConcept C185592680 @default.
• W2028483312 hasConcept C26659971 @default.
• W2028483312 hasConcept C2779222958 @default.
• W2028483312 hasConcept C41625074 @default.
• W2028483312 hasConcept C552990157 @default.
• W2028483312 hasConcept C55493867 @default.
• W2028483312 hasConcept C62520636 @default.
• W2028483312 hasConcept C64927066 @default.
• W2028483312 hasConcept C83640560 @default.
• W2028483312 hasConcept C84772758 @default.
• W2028483312 hasConcept C86803240 @default.
• W2028483312 hasConcept C91881484 @default.
• W2028483312 hasConcept C95444343 @default.
• W2028483312 hasConcept C96305047 @default.
• W2028483312 hasConceptScore W2028483312C104292427 @default.
• W2028483312 hasConceptScore W2028483312C104317684 @default.
• W2028483312 hasConceptScore W2028483312C121332964 @default.
• W2028483312 hasConceptScore W2028483312C12554922 @default.
• W2028483312 hasConceptScore W2028483312C14519417 @default.
• W2028483312 hasConceptScore W2028483312C185592680 @default.
• W2028483312 hasConceptScore W2028483312C26659971 @default.
• W2028483312 hasConceptScore W2028483312C2779222958 @default.
• W2028483312 hasConceptScore W2028483312C41625074 @default.
• W2028483312 hasConceptScore W2028483312C552990157 @default.
• W2028483312 hasConceptScore W2028483312C55493867 @default.
• W2028483312 hasConceptScore W2028483312C62520636 @default.
• W2028483312 hasConceptScore W2028483312C64927066 @default.
• W2028483312 hasConceptScore W2028483312C83640560 @default.
• W2028483312 hasConceptScore W2028483312C84772758 @default.
• W2028483312 hasConceptScore W2028483312C86803240 @default.
• W2028483312 hasConceptScore W2028483312C91881484 @default.
• W2028483312 hasConceptScore W2028483312C95444343 @default.
• W2028483312 hasConceptScore W2028483312C96305047 @default.
• W2028483312 hasIssue "45" @default.
• W2028483312 hasLocation W20284833121 @default.
• W2028483312 hasLocation W20284833122 @default.
• W2028483312 hasLocation W20284833123 @default.

• next