Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028488940> ?p ?o ?g. }
- W2028488940 endingPage "778" @default.
- W2028488940 startingPage "766" @default.
- W2028488940 abstract "In this work we propose a semimechanistic model that describes the photic signal transduction to the hypothalamic-pituitary-adrenal (HPA) axis that ultimately regulates the synchronization of peripheral clock genes (PCGs). Our HPA axis model predicts that photic stimulation induces a type-1 phase response curve to cortisol's profile with increased cortisol sensitivity to light exposure in its rising phase, as well as the shortening of cortisol's period as constant light increases (Aschoff's first rule). Furthermore, our model provides insight into cortisol's phase and amplitude dependence on photoperiods and reveals that cortisol maintains highest amplitude variability when it is entrained by a balanced schedule of light and dark periods. Importantly, by incorporating the links between HPA axis and PCGs we were able to investigate how cortisol secretion impacts the entrainment of a population of peripheral cells and show that disrupted light schedules, leading to blunted cortisol secretion, fail to synchronize a population of PCGs which further signifies the loss of circadian rhythmicity in the periphery of the body." @default.
- W2028488940 created "2016-06-24" @default.
- W2028488940 creator A5000309438 @default.
- W2028488940 creator A5008216940 @default.
- W2028488940 creator A5016501994 @default.
- W2028488940 creator A5049184270 @default.
- W2028488940 date "2014-10-15" @default.
- W2028488940 modified "2023-10-16" @default.
- W2028488940 title "Mathematical modeling of light-mediated HPA axis activity and downstream implications on the entrainment of peripheral clock genes" @default.
- W2028488940 cites W1491201932 @default.
- W2028488940 cites W1535180370 @default.
- W2028488940 cites W1760402555 @default.
- W2028488940 cites W187135256 @default.
- W2028488940 cites W1970434009 @default.
- W2028488940 cites W1973416971 @default.
- W2028488940 cites W1976311248 @default.
- W2028488940 cites W1984158139 @default.
- W2028488940 cites W1985541217 @default.
- W2028488940 cites W1989731551 @default.
- W2028488940 cites W1996486968 @default.
- W2028488940 cites W1998127870 @default.
- W2028488940 cites W1998522501 @default.
- W2028488940 cites W2003302378 @default.
- W2028488940 cites W2015559406 @default.
- W2028488940 cites W2017781886 @default.
- W2028488940 cites W2021607553 @default.
- W2028488940 cites W2022766125 @default.
- W2028488940 cites W2027303619 @default.
- W2028488940 cites W2029323550 @default.
- W2028488940 cites W2030083295 @default.
- W2028488940 cites W2032257769 @default.
- W2028488940 cites W2034585240 @default.
- W2028488940 cites W2036506956 @default.
- W2028488940 cites W2040629892 @default.
- W2028488940 cites W2040650438 @default.
- W2028488940 cites W2041362984 @default.
- W2028488940 cites W2041608117 @default.
- W2028488940 cites W2042661460 @default.
- W2028488940 cites W2046451925 @default.
- W2028488940 cites W2048232312 @default.
- W2028488940 cites W2049777419 @default.
- W2028488940 cites W2053414344 @default.
- W2028488940 cites W2054936731 @default.
- W2028488940 cites W2055145238 @default.
- W2028488940 cites W2057416723 @default.
- W2028488940 cites W2060659587 @default.
- W2028488940 cites W2060925737 @default.
- W2028488940 cites W2062882767 @default.
- W2028488940 cites W2067916571 @default.
- W2028488940 cites W2068648361 @default.
- W2028488940 cites W2068778235 @default.
- W2028488940 cites W2068945449 @default.
- W2028488940 cites W2073353037 @default.
- W2028488940 cites W2074975608 @default.
- W2028488940 cites W2077061053 @default.
- W2028488940 cites W2080240501 @default.
- W2028488940 cites W2082427618 @default.
- W2028488940 cites W2086254264 @default.
- W2028488940 cites W2087352541 @default.
- W2028488940 cites W2088875008 @default.
- W2028488940 cites W2090209293 @default.
- W2028488940 cites W2093612001 @default.
- W2028488940 cites W2094589586 @default.
- W2028488940 cites W2098498582 @default.
- W2028488940 cites W2104605616 @default.
- W2028488940 cites W2105148976 @default.
- W2028488940 cites W2105829321 @default.
- W2028488940 cites W2114608871 @default.
- W2028488940 cites W2116667148 @default.
- W2028488940 cites W2120101711 @default.
- W2028488940 cites W2121978115 @default.
- W2028488940 cites W2122502531 @default.
- W2028488940 cites W2123663957 @default.
- W2028488940 cites W2123914447 @default.
- W2028488940 cites W2127479912 @default.
- W2028488940 cites W2131050167 @default.
- W2028488940 cites W2132022108 @default.
- W2028488940 cites W2139141739 @default.
- W2028488940 cites W2140832481 @default.
- W2028488940 cites W2141401639 @default.
- W2028488940 cites W2143210222 @default.
- W2028488940 cites W2143506081 @default.
- W2028488940 cites W2143921558 @default.
- W2028488940 cites W2145073776 @default.
- W2028488940 cites W2147988479 @default.
- W2028488940 cites W2149487034 @default.
- W2028488940 cites W2149665977 @default.
- W2028488940 cites W2155221301 @default.
- W2028488940 cites W2156404675 @default.
- W2028488940 cites W2159664208 @default.
- W2028488940 cites W2162008969 @default.
- W2028488940 cites W2320349682 @default.
- W2028488940 cites W2606013951 @default.
- W2028488940 doi "https://doi.org/10.1152/physiolgenomics.00026.2014" @default.
- W2028488940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25073602" @default.
- W2028488940 hasPublicationYear "2014" @default.
- W2028488940 type Work @default.
- W2028488940 sameAs 2028488940 @default.