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- W2028494702 abstract "UV-induced cyclobutane pyrimidine dimers (CPDs) are removed with accelerated speed from the transcribed strand of expressed genes in cultured mammalian cells by a process called transcription-coupled repair (TCR). It has been previously shown that this phenomenon has consequences for the molecular nature of the mutations induced by UV-light. Here, we review these data and show that TCR has not only a clear impact on UV-induced mutations in cultured mammalian cells but also on genes involved in tumor formation in the skin of UV-exposed mice. Mutations observed in the p53 gene in UV-induced squamous cell carcinoma are predominantly found at sites of dipyrimidines in the non-transcribed strand. In contrast, in UVC-irradiated Csb−/− Chinese hamster cells and in UVB-induced tumors in the Csb−/− mouse, almost all mutations are at positions of dipyrimidine sites in the transcribed strand of the mutated gene. Csb−/− mice appear to be susceptible to UVB-induced skin cancer in contrast to the human CSB patients. We speculate that the UVB-induced cancer susceptibility of Csb−/− mice is related to the absence of TCR as well as to a lack of a compensating global genome repair system for CPDs in mice." @default.
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- W2028494702 date "2005-09-01" @default.
- W2028494702 modified "2023-10-15" @default.
- W2028494702 title "Transcription-coupled repair: Impact on UV-induced mutagenesis in cultured rodent cells and mouse skin tumors" @default.
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- W2028494702 doi "https://doi.org/10.1016/j.mrfmmm.2005.03.018" @default.
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