FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028495621> ?p ?o ?g. }

• W2028495621 endingPage "2239" @default.
• W2028495621 startingPage "2231" @default.
• W2028495621 abstract "Previously, we reported a novel pressurized olfactory drug (POD) delivery device that deposits aerosolized drug preferentially to upper nasal cavity. This POD device provided sustained central nervous system (CNS) levels of soluble morphine analgesic effects. However, analgesic onset of less soluble fentanyl was more rapid but brief, likely because of hydrophobic fentanyl redistribution readily back to blood. To determine whether fentanyl incorporated into an aerosol-stable liposome that binds to nasal epithelial cells will enhance CNS drug exposure and analgesic effects and reduce plasma exposure, we constructed Arg–Gly–Asp (RGD) liposomes anchored with acylated integrin-binding peptides (palmitoyl–Gly–Arg–Gly–Asp–Ser). The RGD liposomes, which assume gel phase membrane structure at 25°C, were stable under the stress of aerosolization as only 2.2 ± 0.5% calcein leakage was detected. The RGD-mediated integrin binding of liposome is also verified to be unaffected by aerosolization. Rats treated with fentanyl in RGD liposome and POD device exhibited greater analgesic effect, as compared with the free drug counterpart (AUCeffect = 1387.1% vs. 760.1% MPE*min), whereas approximately 20% reduced plasma drug exposure was noted (AUC0–120 = 208.2 vs. 284.8 ng min/mL). Collectively, fentanyl incorporated in RGD liposomes is physically and biologically stable under aerosolization, enhanced the overall analgesic effects, and reduced plasma drug exposure for the first 2 h. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:2231–2239, 2014" @default.
• W2028495621 created "2016-06-24" @default.
• W2028495621 creator A5015522784 @default.
• W2028495621 creator A5037010626 @default.
• W2028495621 creator A5045487241 @default.
• W2028495621 date "2014-08-01" @default.
• W2028495621 modified "2023-09-24" @default.
• W2028495621 title "Aerosol-Stable Peptide-Coated Liposome Nanoparticles: A Proof-of-Concept Study with Opioid Fentanyl in Enhancing Analgesic Effects and Reducing Plasma Drug Exposure" @default.
• W2028495621 cites W163900819 @default.
• W2028495621 cites W1973300659 @default.
• W2028495621 cites W1978216460 @default.
• W2028495621 cites W1988193392 @default.
• W2028495621 cites W1995796610 @default.
• W2028495621 cites W2001525797 @default.
• W2028495621 cites W2010836203 @default.
• W2028495621 cites W2018340655 @default.
• W2028495621 cites W2050204005 @default.
• W2028495621 cites W2051455837 @default.
• W2028495621 cites W2070318626 @default.
• W2028495621 cites W2075800885 @default.
• W2028495621 cites W2078218165 @default.
• W2028495621 cites W2083653139 @default.
• W2028495621 cites W2085003131 @default.
• W2028495621 cites W2089575516 @default.
• W2028495621 cites W2091824676 @default.
• W2028495621 cites W2095008938 @default.
• W2028495621 cites W2115378502 @default.
• W2028495621 cites W2133744014 @default.
• W2028495621 cites W2139714860 @default.
• W2028495621 cites W2148526581 @default.
• W2028495621 cites W231347532 @default.
• W2028495621 doi "https://doi.org/10.1002/jps.24022" @default.
• W2028495621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4115018" @default.
• W2028495621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24909764" @default.
• W2028495621 hasPublicationYear "2014" @default.
• W2028495621 type Work @default.
• W2028495621 sameAs 2028495621 @default.
• W2028495621 citedByCount "22" @default.
• W2028495621 countsByYear W20284956212016 @default.
• W2028495621 countsByYear W20284956212017 @default.
• W2028495621 countsByYear W20284956212018 @default.
• W2028495621 countsByYear W20284956212019 @default.
• W2028495621 countsByYear W20284956212020 @default.
• W2028495621 countsByYear W20284956212021 @default.
• W2028495621 countsByYear W20284956212022 @default.
• W2028495621 countsByYear W20284956212023 @default.
• W2028495621 crossrefType "journal-article" @default.
• W2028495621 hasAuthorship W2028495621A5015522784 @default.
• W2028495621 hasAuthorship W2028495621A5037010626 @default.
• W2028495621 hasAuthorship W2028495621A5045487241 @default.
• W2028495621 hasBestOaLocation W20284956212 @default.
• W2028495621 hasConcept C178790620 @default.
• W2028495621 hasConcept C185154212 @default.
• W2028495621 hasConcept C185592680 @default.
• W2028495621 hasConcept C2776872141 @default.
• W2028495621 hasConcept C2776954882 @default.
• W2028495621 hasConcept C2779820397 @default.
• W2028495621 hasConcept C2780035454 @default.
• W2028495621 hasConcept C2780820201 @default.
• W2028495621 hasConcept C2781072394 @default.
• W2028495621 hasConcept C41625074 @default.
• W2028495621 hasConcept C42219234 @default.
• W2028495621 hasConcept C55493867 @default.
• W2028495621 hasConcept C71924100 @default.
• W2028495621 hasConcept C82085835 @default.
• W2028495621 hasConcept C98274493 @default.
• W2028495621 hasConceptScore W2028495621C178790620 @default.
• W2028495621 hasConceptScore W2028495621C185154212 @default.
• W2028495621 hasConceptScore W2028495621C185592680 @default.
• W2028495621 hasConceptScore W2028495621C2776872141 @default.
• W2028495621 hasConceptScore W2028495621C2776954882 @default.
• W2028495621 hasConceptScore W2028495621C2779820397 @default.
• W2028495621 hasConceptScore W2028495621C2780035454 @default.
• W2028495621 hasConceptScore W2028495621C2780820201 @default.
• W2028495621 hasConceptScore W2028495621C2781072394 @default.
• W2028495621 hasConceptScore W2028495621C41625074 @default.
• W2028495621 hasConceptScore W2028495621C42219234 @default.
• W2028495621 hasConceptScore W2028495621C55493867 @default.
• W2028495621 hasConceptScore W2028495621C71924100 @default.
• W2028495621 hasConceptScore W2028495621C82085835 @default.
• W2028495621 hasConceptScore W2028495621C98274493 @default.
• W2028495621 hasFunder F4320332161 @default.
• W2028495621 hasIssue "8" @default.
• W2028495621 hasLocation W20284956211 @default.
• W2028495621 hasLocation W20284956212 @default.
• W2028495621 hasLocation W20284956213 @default.
• W2028495621 hasLocation W20284956214 @default.
• W2028495621 hasOpenAccess W2028495621 @default.
• W2028495621 hasPrimaryLocation W20284956211 @default.
• W2028495621 hasRelatedWork W1963657239 @default.
• W2028495621 hasRelatedWork W2028495621 @default.
• W2028495621 hasRelatedWork W2124458286 @default.
• W2028495621 hasRelatedWork W2153570759 @default.
• W2028495621 hasRelatedWork W2506563335 @default.
• W2028495621 hasRelatedWork W2892152679 @default.
• W2028495621 hasRelatedWork W2905111812 @default.
• W2028495621 hasRelatedWork W2948450196 @default.
• W2028495621 hasRelatedWork W2952743768 @default.

• next