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• W2028495929 endingPage "182" @default.
• W2028495929 startingPage "168" @default.
• W2028495929 abstract "The contribution of oxidative stress to ischemic brain damage is well established. Nevertheless, for unknown reasons, several clinically tested antioxidant therapies have failed to show benefits in human stroke. Based on our previous in vitro work, we hypothesized that the neuroprotective potency of antioxidants is related to their ability to limit the release of the excitotoxic amino acids glutamate and aspartate. We explored the effects of two antioxidants, tempol and edaravone, on amino acid release in the brain cortex, in a rat model of transient occlusion of the middle cerebral artery (MCAo). Amino acid levels were quantified using a microdialysis approach, with the probe positioned in the ischemic penumbra as verified by a laser Doppler technique. Two-hour MCAo triggered a dramatic increase in the levels of glutamate, aspartate, taurine, and alanine. Microdialysate delivery of 10mM tempol reduced the amino acid release by 60-80%, whereas matching levels of edaravone had no effect. In line with these data, an intracerebroventricular injection of tempol but not edaravone (500 nmol each, 15 min before MCAo) reduced infarction volumes by ~50% and improved neurobehavioral outcomes. In vitro assays showed that tempol was superior at removing superoxide anion, whereas edaravone was more potent at scavenging hydrogen peroxide, hydroxyl radical, and peroxynitrite. Overall, our data suggest that the neuroprotective properties of tempol are probably related to its ability to reduce tissue levels of the superoxide anion and pathological glutamate release and, in such a way, limit progression of brain infarction within ischemic penumbra. These new findings may be instrumental in developing new antioxidant therapies for treatment of stroke." @default.
• W2028495929 created "2016-06-24" @default.
• W2028495929 creator A5000360560 @default.
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• W2028495929 creator A5085880004 @default.
• W2028495929 creator A5089434258 @default.
• W2028495929 creator A5089897405 @default.
• W2028495929 date "2014-12-01" @default.
• W2028495929 modified "2023-10-16" @default.
• W2028495929 title "The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke" @default.
• W2028495929 cites W1480587960 @default.
• W2028495929 cites W1500192109 @default.
• W2028495929 cites W1529955042 @default.
• W2028495929 cites W1558616518 @default.
• W2028495929 cites W1603138796 @default.
• W2028495929 cites W1635047156 @default.
• W2028495929 cites W1686360944 @default.
• W2028495929 cites W1887210332 @default.
• W2028495929 cites W1936866440 @default.
• W2028495929 cites W1966183236 @default.
• W2028495929 cites W1967315269 @default.
• W2028495929 cites W1970684711 @default.
• W2028495929 cites W1971120748 @default.
• W2028495929 cites W1972958285 @default.
• W2028495929 cites W1973442252 @default.
• W2028495929 cites W1979536838 @default.
• W2028495929 cites W1979561481 @default.
• W2028495929 cites W1982422779 @default.
• W2028495929 cites W1983310681 @default.
• W2028495929 cites W1986082857 @default.
• W2028495929 cites W1988086690 @default.
• W2028495929 cites W1994757585 @default.
• W2028495929 cites W1997684038 @default.
• W2028495929 cites W1999447004 @default.
• W2028495929 cites W2000397596 @default.
• W2028495929 cites W2002729523 @default.
• W2028495929 cites W2003633558 @default.
• W2028495929 cites W2006842487 @default.
• W2028495929 cites W2007453287 @default.
• W2028495929 cites W2013900800 @default.
• W2028495929 cites W2016759315 @default.
• W2028495929 cites W2016997908 @default.
• W2028495929 cites W2020247531 @default.
• W2028495929 cites W2024950660 @default.
• W2028495929 cites W2031511345 @default.
• W2028495929 cites W2031596649 @default.
• W2028495929 cites W2031934521 @default.
• W2028495929 cites W2033278414 @default.
• W2028495929 cites W2033573399 @default.
• W2028495929 cites W2035750459 @default.
• W2028495929 cites W2044394663 @default.
• W2028495929 cites W2045925277 @default.
• W2028495929 cites W2046340393 @default.
• W2028495929 cites W2047230408 @default.
• W2028495929 cites W2047687479 @default.
• W2028495929 cites W2050467591 @default.
• W2028495929 cites W2053847470 @default.
• W2028495929 cites W2056135909 @default.
• W2028495929 cites W2056250939 @default.
• W2028495929 cites W2058013605 @default.
• W2028495929 cites W2058382351 @default.
• W2028495929 cites W2059119335 @default.
• W2028495929 cites W2060060832 @default.
• W2028495929 cites W2062639408 @default.
• W2028495929 cites W2064546177 @default.
• W2028495929 cites W2067363621 @default.
• W2028495929 cites W2068121825 @default.
• W2028495929 cites W2074187719 @default.
• W2028495929 cites W2080279037 @default.
• W2028495929 cites W2080545947 @default.
• W2028495929 cites W2089136890 @default.
• W2028495929 cites W2094996078 @default.
• W2028495929 cites W2103300387 @default.
• W2028495929 cites W2105651021 @default.
• W2028495929 cites W2112505121 @default.
• W2028495929 cites W2122386753 @default.
• W2028495929 cites W2124017577 @default.
• W2028495929 cites W2125065061 @default.
• W2028495929 cites W2126190154 @default.
• W2028495929 cites W2137232579 @default.
• W2028495929 cites W2140936548 @default.
• W2028495929 cites W2144025192 @default.
• W2028495929 cites W2144725892 @default.
• W2028495929 cites W2144918294 @default.
• W2028495929 cites W2155314733 @default.
• W2028495929 cites W2155885439 @default.
• W2028495929 cites W2157282680 @default.
• W2028495929 cites W2158052892 @default.
• W2028495929 cites W2158500293 @default.
• W2028495929 cites W2165523421 @default.
• W2028495929 cites W2169079203 @default.
• W2028495929 cites W2188308812 @default.
• W2028495929 cites W2317448591 @default.
• W2028495929 cites W2344907336 @default.

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