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• W2028503370 abstract "A series of cis-1,2-diaminocyclohexane derivatives possessing a 6–6 fused ring for the S1 moiety were synthesized as novel factor Xa (fXa) inhibitors. The synthesis, structure–activity relationship (SAR), and physicochemical properties are reported herein, together with the discovery of compound 45c, which has potent anti-fXa activity, good physicochemical properties and pharmacokinetic (PK) profiles, including a reduced negative food effect." @default.
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• W2028503370 date "2009-12-15" @default.
• W2028503370 modified "2023-10-17" @default.
• W2028503370 title "Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6–6 fused rings as alternative S1 moieties" @default.
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• W2028503370 doi "https://doi.org/10.1016/j.bmc.2009.10.024" @default.
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