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- W2028505792 abstract "A new kind of complex prepared from scandium(III) triflate and l-proline-derived N,N'-dioxides has been developed to catalyze the enantioselective aza-Diels-Alder reaction between 1,3-butadiene (diene 1) and aldimines 2, affording the corresponding 2,5-disubstituted dihydropyridinones in moderate to high yields (up to 92%) with good enantioselectivities (up to 90% ee) at room temperature. A variety of aldimines including aromatic, heteroaromatic, conjugated, and aliphatic imines were found to be suitable substrates. Enantiopure samples (up to 99% ee) were obtained for some products by a single recrystallization. The absolute configuration of the products was determined by X-ray diffraction and CD analysis. On the basis of the investigation of 1H NMR spectra and the positive nonlinear effect, the catalyst structure was carefully discussed." @default.
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- W2028505792 date "2007-12-19" @default.
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- W2028505792 title "Enantioselective Aza-Diels−Alder Reaction of Aldimines with “Danishefsky-Type Diene” Catalyzed by Chiral Scandium(III)-<i>N</i>,<i>N</i><i>‘</i>-Dioxide Complexes" @default.
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- W2028505792 doi "https://doi.org/10.1021/jo7021263" @default.
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