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- W2028506173 abstract "Abstract The relative extent of tritium labeling in glucose and water was determined when l -[2- 3 H]lactate or [(1 R )1- 3 H]ethanol were the labeled substrates for rat liver parenchymal cells, incubated with 20 m m ethanol and 10 m m l-lactate. From the relatively lower specific yield in glucose from the tritiated ethanol one can calculate a percentage contribution of a non-alcohol dehydrogenase-mediated pathway to total ethanol metabolism. This calculated value (about 35%) is somewhat higher than that determined by the use of pyrazole at 5 m m to inhibit alcohol dehydrogenase. The utilization of [(1 R )1- 3 H]ethanol is slower than that of unlabeled ethanol, both in the absence and presence of 5 m m pyrazole, indicating isotope discrimination against tritium in both the alcohol dehydrogenase and non-alcohol dehydrogenase pathways. There was only a slight difference in the rate of utilization of normal and fully deuterated ethanol by rat liver cells in the absence of pyrazole. However, in the presence of 5 m m pyrazole, where essentially only the non-alcohol dehydrogenase pathway operates, deuterated ethanol was utilized at only about half the rate of nondeuterated ethanol. These findings are difficult to reconcile with a catalase-mediated pathway of ethanol metabolism in which the rate-limiting factor is the rate of H 2 O 2 generation." @default.
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- W2028506173 date "1974-08-01" @default.
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- W2028506173 title "Isotopic probes into pathways of ethanol metabolism" @default.
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- W2028506173 doi "https://doi.org/10.1016/0003-9861(74)90513-x" @default.
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