FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028521552> ?p ?o ?g. }

• W2028521552 endingPage "768" @default.
• W2028521552 startingPage "753" @default.
• W2028521552 abstract "It has been demonstrated that the decoction of the aerial parts of Tagetes lucida Cav. produces an antidepressant effect during the forced swimming test (FST) in rats. The aim of this study was to evaluate the effect of different organic extracts and one aqueous extract of the aerial parts of T. lucida on the FST. In addition, the possible involvement of the serotonergic system in the antidepressant-like effect of T. lucida in the FST was evaluated, as was its potential toxicological effect. The different extracts of T. lucida (methanol, hexane, dichloromethane and aqueous, 10 and 50 mg/kg), as well as fluoxetine (FLX, 5 mg/kg), were administered per os (p.o.) to rats for 14 days. All animals were subjected to the FST. Only the aqueous extract of T. lucida at a dose of 50 mg/kg significantly reduced immobility behavior and increased swimming in the FST, similar to FLX. Later, the aqueous extract of T. lucida (50mg/kg) was administered for 1, 7 and 14 days. An antidepressant effect was observed after 7 days of treatment. To evaluate the participation of the serotoninergic system, the animals were pretreated with PCPA, an inhibitor of serotonin synthesis (100 mg/kg/day for 4 consecutive days). The animals were treated with the aqueous extract of T. lucida (50 mg/kg) and FLX (5 mg/kg) 24 h after the final injection and were then subjected to the FST. Pretreatment with PCPA inhibited the antidepressant effect of both T. lucida and FLX. Finally, T. lucida was administered p.o. and intraperitoneal route to evaluate its acute toxicological effect. The aqueous extract of T. lucida, administered p.o., did not produce lethality or any significant changes in behavior. In conclusion, the aqueous extract of T. lucida manifested an antidepressant-like effect in the FST mediated by the serotonergic system, with no adverse effects when administered p.o." @default.
• W2028521552 created "2016-06-24" @default.
• W2028521552 creator A5018370239 @default.
• W2028521552 creator A5027709427 @default.
• W2028521552 creator A5031826931 @default.
• W2028521552 creator A5087795470 @default.
• W2028521552 creator A5091769566 @default.
• W2028521552 date "2012-01-01" @default.
• W2028521552 modified "2023-10-13" @default.
• W2028521552 title "Antidepressant-Like Effect of <i>Tagetes lucida</i> Cav. Extract in Rats: Involvement of the Serotonergic System" @default.
• W2028521552 cites W1964516381 @default.
• W2028521552 cites W1967421959 @default.
• W2028521552 cites W1970131169 @default.
• W2028521552 cites W1971005654 @default.
• W2028521552 cites W1971940366 @default.
• W2028521552 cites W1977050062 @default.
• W2028521552 cites W1979475203 @default.
• W2028521552 cites W1996366582 @default.
• W2028521552 cites W2002671738 @default.
• W2028521552 cites W2003973769 @default.
• W2028521552 cites W2005594217 @default.
• W2028521552 cites W2012250334 @default.
• W2028521552 cites W2028488334 @default.
• W2028521552 cites W2034302695 @default.
• W2028521552 cites W2036288909 @default.
• W2028521552 cites W2040927330 @default.
• W2028521552 cites W2045035877 @default.
• W2028521552 cites W2050632824 @default.
• W2028521552 cites W2053472601 @default.
• W2028521552 cites W2059688794 @default.
• W2028521552 cites W2068405118 @default.
• W2028521552 cites W2068608435 @default.
• W2028521552 cites W2073924899 @default.
• W2028521552 cites W2076258960 @default.
• W2028521552 cites W2077591716 @default.
• W2028521552 cites W2080070801 @default.
• W2028521552 cites W2080830237 @default.
• W2028521552 cites W2081198551 @default.
• W2028521552 cites W2082841063 @default.
• W2028521552 cites W2083887227 @default.
• W2028521552 cites W2089299823 @default.
• W2028521552 cites W2091064555 @default.
• W2028521552 cites W2091343206 @default.
• W2028521552 cites W2093823567 @default.
• W2028521552 cites W2131167630 @default.
• W2028521552 cites W2143499999 @default.
• W2028521552 cites W2153488247 @default.
• W2028521552 cites W2157085359 @default.
• W2028521552 cites W2158562888 @default.
• W2028521552 cites W2168080346 @default.
• W2028521552 doi "https://doi.org/10.1142/s0192415x12500565" @default.
• W2028521552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22809029" @default.
• W2028521552 hasPublicationYear "2012" @default.
• W2028521552 type Work @default.
• W2028521552 sameAs 2028521552 @default.
• W2028521552 citedByCount "25" @default.
• W2028521552 countsByYear W20285215522013 @default.
• W2028521552 countsByYear W20285215522014 @default.
• W2028521552 countsByYear W20285215522015 @default.
• W2028521552 countsByYear W20285215522016 @default.
• W2028521552 countsByYear W20285215522018 @default.
• W2028521552 countsByYear W20285215522019 @default.
• W2028521552 countsByYear W20285215522020 @default.
• W2028521552 countsByYear W20285215522021 @default.
• W2028521552 countsByYear W20285215522022 @default.
• W2028521552 countsByYear W20285215522023 @default.
• W2028521552 crossrefType "journal-article" @default.
• W2028521552 hasAuthorship W2028521552A5018370239 @default.
• W2028521552 hasAuthorship W2028521552A5027709427 @default.
• W2028521552 hasAuthorship W2028521552A5031826931 @default.
• W2028521552 hasAuthorship W2028521552A5087795470 @default.
• W2028521552 hasAuthorship W2028521552A5091769566 @default.
• W2028521552 hasConcept C134018914 @default.
• W2028521552 hasConcept C170493617 @default.
• W2028521552 hasConcept C185592680 @default.
• W2028521552 hasConcept C190409667 @default.
• W2028521552 hasConcept C2775864247 @default.
• W2028521552 hasConcept C2779177272 @default.
• W2028521552 hasConcept C2781161787 @default.
• W2028521552 hasConcept C2993907526 @default.
• W2028521552 hasConcept C37000724 @default.
• W2028521552 hasConcept C55493867 @default.
• W2028521552 hasConcept C556039675 @default.
• W2028521552 hasConcept C71924100 @default.
• W2028521552 hasConcept C86803240 @default.
• W2028521552 hasConcept C98274493 @default.
• W2028521552 hasConceptScore W2028521552C134018914 @default.
• W2028521552 hasConceptScore W2028521552C170493617 @default.
• W2028521552 hasConceptScore W2028521552C185592680 @default.
• W2028521552 hasConceptScore W2028521552C190409667 @default.
• W2028521552 hasConceptScore W2028521552C2775864247 @default.
• W2028521552 hasConceptScore W2028521552C2779177272 @default.
• W2028521552 hasConceptScore W2028521552C2781161787 @default.
• W2028521552 hasConceptScore W2028521552C2993907526 @default.
• W2028521552 hasConceptScore W2028521552C37000724 @default.
• W2028521552 hasConceptScore W2028521552C55493867 @default.
• W2028521552 hasConceptScore W2028521552C556039675 @default.
• W2028521552 hasConceptScore W2028521552C71924100 @default.

• next