Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028521696> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2028521696 endingPage "549" @default.
- W2028521696 startingPage "543" @default.
- W2028521696 abstract "A comparative pharmacokinetic study of theophylline between the first and repeated oral administration and the assessment of clinical utility of theophylline test-dose concept were performed in 6 (study I) and 4 (study II) healthy male volunteers with different dosing schedules. In study I, although the average of theophylline systemic clearance (Clsys) was significantly (p less than 0.05) lower in the repeated dosing than in the first dosing, large intersubject variations were observed. Plasma free fatty acids which inhibit drug metabolizing enzyme activity were not influenced by theophylline chronic administration. In study II, the volunteers received oral multiple doses of a theophylline powder preparation to maintain 5 to 15 micrograms/ml plasma concentration on the basis of the pharmacokinetic parameters calculated from the single oral test-dose. A good prediction of the plasma concentration was observed only in one case and the maximum levels in the rest exceeded 20 micrograms/ml, a toxic concentration. Throughout the Studies, a stable Clsys was obtained in smokers, but the Clsys in non-smokers decreased by one third to a half during multiple dosing. These findings suggest that theophylline showed time-dependent pharmacokinetics and that test-dose concept for theophylline may not be applicable in all cases because of a large intersubject variation in the Clsys change between single and multiple dosing." @default.
- W2028521696 created "2016-06-24" @default.
- W2028521696 creator A5009996351 @default.
- W2028521696 creator A5010904667 @default.
- W2028521696 creator A5013335631 @default.
- W2028521696 creator A5049913424 @default.
- W2028521696 creator A5070455102 @default.
- W2028521696 date "1987-01-01" @default.
- W2028521696 modified "2023-10-17" @default.
- W2028521696 title "Time-dependent pharmacokinetics of theophylline: Failure of application of the test-dose concept." @default.
- W2028521696 cites W1949185870 @default.
- W2028521696 cites W1964611758 @default.
- W2028521696 cites W1965506676 @default.
- W2028521696 cites W1973050732 @default.
- W2028521696 cites W1977435829 @default.
- W2028521696 cites W1980321977 @default.
- W2028521696 cites W1980871523 @default.
- W2028521696 cites W1987150372 @default.
- W2028521696 cites W1989467658 @default.
- W2028521696 cites W2005584393 @default.
- W2028521696 cites W2008434478 @default.
- W2028521696 cites W2011520415 @default.
- W2028521696 cites W2019902007 @default.
- W2028521696 cites W2023454879 @default.
- W2028521696 cites W2026004277 @default.
- W2028521696 cites W2036184907 @default.
- W2028521696 cites W2037173390 @default.
- W2028521696 cites W2052355984 @default.
- W2028521696 cites W2063178701 @default.
- W2028521696 cites W2070478670 @default.
- W2028521696 cites W2078593475 @default.
- W2028521696 cites W2083381456 @default.
- W2028521696 cites W2087526401 @default.
- W2028521696 cites W2095396653 @default.
- W2028521696 cites W2119551113 @default.
- W2028521696 cites W2167983781 @default.
- W2028521696 cites W2223322542 @default.
- W2028521696 cites W2264718489 @default.
- W2028521696 cites W2329991533 @default.
- W2028521696 cites W2410720625 @default.
- W2028521696 cites W2431089081 @default.
- W2028521696 cites W70411751 @default.
- W2028521696 doi "https://doi.org/10.1248/bpb1978.10.543" @default.
- W2028521696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3440916" @default.
- W2028521696 hasPublicationYear "1987" @default.
- W2028521696 type Work @default.
- W2028521696 sameAs 2028521696 @default.
- W2028521696 citedByCount "1" @default.
- W2028521696 crossrefType "journal-article" @default.
- W2028521696 hasAuthorship W2028521696A5009996351 @default.
- W2028521696 hasAuthorship W2028521696A5010904667 @default.
- W2028521696 hasAuthorship W2028521696A5013335631 @default.
- W2028521696 hasAuthorship W2028521696A5049913424 @default.
- W2028521696 hasAuthorship W2028521696A5070455102 @default.
- W2028521696 hasBestOaLocation W20285216961 @default.
- W2028521696 hasConcept C112705442 @default.
- W2028521696 hasConcept C126322002 @default.
- W2028521696 hasConcept C19831878 @default.
- W2028521696 hasConcept C2776042228 @default.
- W2028521696 hasConcept C2777056448 @default.
- W2028521696 hasConcept C2777288759 @default.
- W2028521696 hasConcept C2778095195 @default.
- W2028521696 hasConcept C2780035454 @default.
- W2028521696 hasConcept C2781018748 @default.
- W2028521696 hasConcept C71924100 @default.
- W2028521696 hasConcept C98274493 @default.
- W2028521696 hasConceptScore W2028521696C112705442 @default.
- W2028521696 hasConceptScore W2028521696C126322002 @default.
- W2028521696 hasConceptScore W2028521696C19831878 @default.
- W2028521696 hasConceptScore W2028521696C2776042228 @default.
- W2028521696 hasConceptScore W2028521696C2777056448 @default.
- W2028521696 hasConceptScore W2028521696C2777288759 @default.
- W2028521696 hasConceptScore W2028521696C2778095195 @default.
- W2028521696 hasConceptScore W2028521696C2780035454 @default.
- W2028521696 hasConceptScore W2028521696C2781018748 @default.
- W2028521696 hasConceptScore W2028521696C71924100 @default.
- W2028521696 hasConceptScore W2028521696C98274493 @default.
- W2028521696 hasIssue "10" @default.
- W2028521696 hasLocation W20285216961 @default.
- W2028521696 hasLocation W20285216962 @default.
- W2028521696 hasOpenAccess W2028521696 @default.
- W2028521696 hasPrimaryLocation W20285216961 @default.
- W2028521696 hasRelatedWork W1554211866 @default.
- W2028521696 hasRelatedWork W2004325424 @default.
- W2028521696 hasRelatedWork W2019391076 @default.
- W2028521696 hasRelatedWork W2028521696 @default.
- W2028521696 hasRelatedWork W2036097956 @default.
- W2028521696 hasRelatedWork W2042130455 @default.
- W2028521696 hasRelatedWork W2062485642 @default.
- W2028521696 hasRelatedWork W2164754849 @default.
- W2028521696 hasRelatedWork W2426732143 @default.
- W2028521696 hasRelatedWork W2793520024 @default.
- W2028521696 hasVolume "10" @default.
- W2028521696 isParatext "false" @default.
- W2028521696 isRetracted "false" @default.
- W2028521696 magId "2028521696" @default.
- W2028521696 workType "article" @default.