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- W2028522577 abstract "Aminoethylcarbamoyl-polyrotaxanes (AEC-α/E35-TYR-Zs) were synthesized as a novel cationic polymer for DNA complexation and characterized in terms of physicochemical properties of polyion complex. Here, AEC groups were introduced to hydroxyl groups of α-cyclodextrins (α-CDs) that are threaded onto a poly(ethylene glycol) (PEG) chain capped with bulky end-groups (polyrotaxane). We examined the ability of DNA complexation of the AEC-α/E35-TYR-Zs compared with polyethylenimine (PEI). Agarose gel shift assay and ethydium bromide (EB) displacement analysis showed that the number of threading α-CDs was one of the dominant factors to enhance the ability of DNA complexation. In addition, increasing the number of AEC groups in the AEC-α/E35-TYR-Zs led to tighter complexation." @default.
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- W2028522577 date "2004-01-01" @default.
- W2028522577 modified "2023-10-18" @default.
- W2028522577 title "Effects of polyrotaxane structure on polyion complexation with DNA" @default.
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- W2028522577 doi "https://doi.org/10.1016/j.stam.2003.12.014" @default.
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