Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028536698> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2028536698 endingPage "2828" @default.
- W2028536698 startingPage "2824" @default.
- W2028536698 abstract "Homothallic strains of Saccharomyces cerevisiae can switch from one mating type to the other as often as every cell division. The conversion of mating type alleles (from MAT a to MAT α or vice versa ) depends on other, unexpressed copies of a or α information that can be transposed to MAT . Previously, “inconvertible” mutations within MAT α and MAT a have been described that block the excision of the MAT allele. In this paper we describe two cis -acting mutations that also impair mating type switching and lie very near, but outside, the MAT locus. Both “stuck” mutations, stk1 and stk2 , diminish the efficiency of converting MAT a to MAT α to less than 10% of normal. The stk1 mutation also slightly reduces conversion of MAT α to MAT a, whereas stk2 has no discernible effect. Unlike the inconvertible MAT α- inc and MAT a- inc mutations within MAT , the stk mutations are not replaced by wild-type sequences after the “stuck” cells occasionally switch to the opposite mating type. Because these mutations are not “healed” by mating type conversions, they must lie in sequences outside of the transposable mating type information. These results indicate that the efficient replacement of MAT alleles depends on sequences both within and adjacent to the MAT locus. Among subclones of homothallic stk MAT a strains, approximately 2% show “illegal” transpositions of mating type genes. In these colonies the silent copy of α information at the HML α locus has been converted to a, without any change of MAT a or the silent a copy at HMR a. Such conversions of the unexpressed library genes are not found in wild-type homothallic strains that can switch mating type efficiently, but they are found in MAT a- inc and MAT α- inc strains. It appears that all of the cis -acting mutations within or adjacent to mating type result in these unusual switches of mating type information at HML and HMR ." @default.
- W2028536698 created "2016-06-24" @default.
- W2028536698 creator A5014990971 @default.
- W2028536698 creator A5018638052 @default.
- W2028536698 creator A5021747654 @default.
- W2028536698 creator A5048113506 @default.
- W2028536698 creator A5068764134 @default.
- W2028536698 date "1980-05-01" @default.
- W2028536698 modified "2023-09-23" @default.
- W2028536698 title "Mutations preventing transpositions of yeast mating type alleles" @default.
- W2028536698 cites W1825047037 @default.
- W2028536698 cites W1932527069 @default.
- W2028536698 cites W1968916548 @default.
- W2028536698 cites W1989252215 @default.
- W2028536698 cites W1997015356 @default.
- W2028536698 cites W2019840836 @default.
- W2028536698 cites W2039850729 @default.
- W2028536698 cites W2053350392 @default.
- W2028536698 cites W2055645382 @default.
- W2028536698 cites W2142515380 @default.
- W2028536698 cites W2143926208 @default.
- W2028536698 cites W2157724881 @default.
- W2028536698 cites W2184477306 @default.
- W2028536698 cites W2189220566 @default.
- W2028536698 cites W2200590286 @default.
- W2028536698 cites W2343728082 @default.
- W2028536698 doi "https://doi.org/10.1073/pnas.77.5.2824" @default.
- W2028536698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/349497" @default.
- W2028536698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6248869" @default.
- W2028536698 hasPublicationYear "1980" @default.
- W2028536698 type Work @default.
- W2028536698 sameAs 2028536698 @default.
- W2028536698 citedByCount "24" @default.
- W2028536698 countsByYear W20285366982020 @default.
- W2028536698 countsByYear W20285366982021 @default.
- W2028536698 countsByYear W20285366982023 @default.
- W2028536698 crossrefType "journal-article" @default.
- W2028536698 hasAuthorship W2028536698A5014990971 @default.
- W2028536698 hasAuthorship W2028536698A5018638052 @default.
- W2028536698 hasAuthorship W2028536698A5021747654 @default.
- W2028536698 hasAuthorship W2028536698A5048113506 @default.
- W2028536698 hasAuthorship W2028536698A5068764134 @default.
- W2028536698 hasBestOaLocation W20285366981 @default.
- W2028536698 hasConcept C104317684 @default.
- W2028536698 hasConcept C112212490 @default.
- W2028536698 hasConcept C143065580 @default.
- W2028536698 hasConcept C180754005 @default.
- W2028536698 hasConcept C187489309 @default.
- W2028536698 hasConcept C198348125 @default.
- W2028536698 hasConcept C207583985 @default.
- W2028536698 hasConcept C2777576037 @default.
- W2028536698 hasConcept C44731419 @default.
- W2028536698 hasConcept C46909000 @default.
- W2028536698 hasConcept C4918238 @default.
- W2028536698 hasConcept C54355233 @default.
- W2028536698 hasConcept C84597430 @default.
- W2028536698 hasConcept C86803240 @default.
- W2028536698 hasConceptScore W2028536698C104317684 @default.
- W2028536698 hasConceptScore W2028536698C112212490 @default.
- W2028536698 hasConceptScore W2028536698C143065580 @default.
- W2028536698 hasConceptScore W2028536698C180754005 @default.
- W2028536698 hasConceptScore W2028536698C187489309 @default.
- W2028536698 hasConceptScore W2028536698C198348125 @default.
- W2028536698 hasConceptScore W2028536698C207583985 @default.
- W2028536698 hasConceptScore W2028536698C2777576037 @default.
- W2028536698 hasConceptScore W2028536698C44731419 @default.
- W2028536698 hasConceptScore W2028536698C46909000 @default.
- W2028536698 hasConceptScore W2028536698C4918238 @default.
- W2028536698 hasConceptScore W2028536698C54355233 @default.
- W2028536698 hasConceptScore W2028536698C84597430 @default.
- W2028536698 hasConceptScore W2028536698C86803240 @default.
- W2028536698 hasIssue "5" @default.
- W2028536698 hasLocation W20285366981 @default.
- W2028536698 hasLocation W20285366982 @default.
- W2028536698 hasLocation W20285366983 @default.
- W2028536698 hasLocation W20285366984 @default.
- W2028536698 hasOpenAccess W2028536698 @default.
- W2028536698 hasPrimaryLocation W20285366981 @default.
- W2028536698 hasRelatedWork W1676953906 @default.
- W2028536698 hasRelatedWork W2019840836 @default.
- W2028536698 hasRelatedWork W2028536698 @default.
- W2028536698 hasRelatedWork W2070637617 @default.
- W2028536698 hasRelatedWork W2141325051 @default.
- W2028536698 hasRelatedWork W2142515380 @default.
- W2028536698 hasRelatedWork W2144082638 @default.
- W2028536698 hasRelatedWork W2164999901 @default.
- W2028536698 hasRelatedWork W4238559631 @default.
- W2028536698 hasRelatedWork W2254519397 @default.
- W2028536698 hasVolume "77" @default.
- W2028536698 isParatext "false" @default.
- W2028536698 isRetracted "false" @default.
- W2028536698 magId "2028536698" @default.
- W2028536698 workType "article" @default.