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- W2028541244 abstract "Using a large retrospective case-control study we sought to investigate the effectiveness of a combined co-treatment with aspirin, doxycycline, prednisolone ± luteal phase estradiol patches (treatment) on average number of oocytes collected (O), fertilisation (FR), clinical pregnancy (PR) and live birth (LBR) rates in fresh and frozen IVF/microinjection (ICSI) cycles. A 1:1 matched case control study at Monash IVF from 2005-2008. The total number of cycles was 970 with 324 fresh cycles pairs and 161 frozen cycle pairs. Cycles were matched for number of embryos transferred (ET), day of transfer, insemination method, patient age, stimulation cycle number. 254 patients had aspirin, doxycycline and prednisolone and 231 had the same drugs with estradiol. Data were analysed using Chi-square tests for categorical variables and independent samples and t-test for comparison of group means. Data are presented as frequency (%) and mean ( ± SD). P <0.05 was considered statistically significant. We found no difference in O, PR or LBR when co-treatments with or without estradiol were investigated separately, hence the grouping of the treatments. There was also no difference in outcomes between treatment and control groups in IVF or ICSI cycles. As table 1 shows, there was a detrimental affect on LBR for frozen cycles when co-treatments were used.Table 1TreatmentControlP ValueO7.7( ± 6.5)8( ± 6.8)0.54FR79.3%81.1%0.23PRFresh38.9%38.6%0.94Frozen16.8%23.0%0.16LBRFresh32.7%32.7%1Frozen9.3%17.4%0.03** = Significantly different Open table in a new tab * = Significantly different When the matched pairs were examined according to number of stimulated cycles (SC) 1 or 2 compared with ≥3, the implantation rate was lower in the treatment group SC1or2 (21.4%) compared with 30.1% in control (P=0.03). Miscarriage rates were significantly higher (P=0.02) in the SC≥3 treatment (25%) compared to 10.3% in control. This matched case-control study does not provide support for the continued use of these addjuvants in IVF patients." @default.
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- W2028541244 date "2011-09-01" @default.
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- W2028541244 title "Add ONS for in vitro fertilisaton (IVF). An act of desperation?" @default.
- W2028541244 doi "https://doi.org/10.1016/j.fertnstert.2011.07.1013" @default.
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