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- W2028542661 abstract "WE have cultured neurones from the developing cortex of mice that have had the amyloid precursor protein gene deleted (APP-null). Neurones cultured for a period of 24 h show similar neurite outgrowth and survival responses to wild-type neurones. Similar neurite outgrowth responses were also seen when neurones from APP-null mice were treated with a neurotrophic peptide derived from the APP sequence and compared with wild-type neurones. Finally, cortical cultures derived from APP-null mice showed similar survival responses to the toxic amyloid-β peptide." @default.
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- W2028542661 date "1998-09-01" @default.
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- W2028542661 title "Mouse cortical neurones lacking APP show normal neurite outgrowth and survival responses in vitro" @default.
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- W2028542661 doi "https://doi.org/10.1097/00001756-199809140-00025" @default.
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