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- W2028542922 abstract "In order to determine base requirements in loops 2 and 4 of the hairpin ribozyme, a comprehensive mutational analysis of the wild type sequence was done. Each base position in these two loops was mutated to contain each of the three non-wild type bases, and the effects of these mutations were analyzed using cis-cleavage assays. The method of data analysis allowed for the determination of self-cleavage rates as well as the fraction of transcripts produced which were uncleavable. Three positions in loop 2 (A22, A23, and C25) and one position in loop 4 (A38) resulted in no detectable self-cleavage when mutated to any of the non-wild type bases. The remainder of the base positions showed varying degrees of tolerance to base mutations with respect to their support of cis-cleavage. Evidence was obtained for the presence of a non-Watson-Crick base pair between A26 and G36 in the catalytic conformation of the hairpin ribozyme. On the basis of these results, a two-dimensional model for the hairpin ribozyme is presented." @default.
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- W2028542922 date "1997-04-01" @default.
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- W2028542922 title "Analysis of Hairpin Ribozyme Base Mutations in Loops 2 and 4 and Their Effects on <i>cis</i>-Cleavage <i>in </i><i>Vitro</i>" @default.
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- W2028542922 doi "https://doi.org/10.1021/bi9628735" @default.
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