FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028544060> ?p ?o ?g. }

• W2028544060 endingPage "62" @default.
• W2028544060 startingPage "53" @default.
• W2028544060 abstract "We have previously reported that autocrine secretion of insulin-like growth factor-II (IGF-II) plays a critical role in stimulating spontaneous myogenic differentiation in vitro. Myogenesis and IGF-II gene expression are both negatively controlled by high serum growth medium, and it is likely that serum inhibits terminal differentiation at least in part by blocking autocrine secretion of IGF-II. To investigate this possibility, we assessed the effects of various serum fractions and growth factors on endogenous IGF-II gene expression in rat L6A1 myoblasts. Unexpectedly, we found that IGF-I, IGF-II, and high concentrations of insulin were potent inhibitors of IGF-II gene expression. This is the first example we have seen in which IGFs regulate their own expression by a negative feedback mechanism. Feedback inhibition was not dependent on the stimulation of cell proliferation by IGFs, and differentiated L6A1 myotubes remained sensitive to this action of the IGFs. Results with IGF analogs suggested that the inhibition of IGF-II gene expression by IGFs was mediated by the type I IGF receptor and was strongly suppressed by L6A1-secreted IGF-binding proteins. Human primary myoblasts also exhibited feedback inhibition by the IGFs, whereas the rapidly fusing mouse Sol 8 cell line did not. We conclude that IGF-II gene expression in differentiating L6A1 myoblasts is regulated by a negative feedback mechanism (unusual for the IGFs) that acts primarily through the type I IGF receptor and appears to be inhibited by IGF-binding proteins secreted by L6A1 myoblasts in low serum differentiation medium." @default.
• W2028544060 created "2016-06-24" @default.
• W2028544060 creator A5016783246 @default.
• W2028544060 creator A5031238366 @default.
• W2028544060 creator A5068699692 @default.
• W2028544060 creator A5087938172 @default.
• W2028544060 date "1994-07-01" @default.
• W2028544060 modified "2023-10-15" @default.
• W2028544060 title "Negative feedback regulation of insulin-like growth factor-II gene expression in differentiating myoblasts in vitro." @default.
• W2028544060 cites W1493449863 @default.
• W2028544060 cites W1495959646 @default.
• W2028544060 cites W1511815713 @default.
• W2028544060 cites W1542955689 @default.
• W2028544060 cites W1551359041 @default.
• W2028544060 cites W1593480031 @default.
• W2028544060 cites W1821344948 @default.
• W2028544060 cites W1971242913 @default.
• W2028544060 cites W1971661586 @default.
• W2028544060 cites W1973036920 @default.
• W2028544060 cites W1973500578 @default.
• W2028544060 cites W1979046428 @default.
• W2028544060 cites W1980099872 @default.
• W2028544060 cites W1981670577 @default.
• W2028544060 cites W1986877280 @default.
• W2028544060 cites W1987726188 @default.
• W2028544060 cites W1991750878 @default.
• W2028544060 cites W1996626295 @default.
• W2028544060 cites W2000728394 @default.
• W2028544060 cites W2001999755 @default.
• W2028544060 cites W2002841462 @default.
• W2028544060 cites W2012460468 @default.
• W2028544060 cites W2014178753 @default.
• W2028544060 cites W2046514538 @default.
• W2028544060 cites W2048527923 @default.
• W2028544060 cites W2049775377 @default.
• W2028544060 cites W2064683528 @default.
• W2028544060 cites W2065995727 @default.
• W2028544060 cites W2072462218 @default.
• W2028544060 cites W2091802684 @default.
• W2028544060 cites W2100278794 @default.
• W2028544060 cites W2101333220 @default.
• W2028544060 cites W2101467051 @default.
• W2028544060 cites W2123251689 @default.
• W2028544060 cites W2134812217 @default.
• W2028544060 cites W2147218892 @default.
• W2028544060 cites W2148585145 @default.
• W2028544060 cites W2150096453 @default.
• W2028544060 cites W2165220352 @default.
• W2028544060 cites W2188127425 @default.
• W2028544060 cites W2277867090 @default.
• W2028544060 cites W2341028512 @default.
• W2028544060 cites W2345970046 @default.
• W2028544060 cites W2409094784 @default.
• W2028544060 doi "https://doi.org/10.1210/endo.135.1.8013391" @default.
• W2028544060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8013391" @default.
• W2028544060 hasPublicationYear "1994" @default.
• W2028544060 type Work @default.
• W2028544060 sameAs 2028544060 @default.
• W2028544060 citedByCount "28" @default.
• W2028544060 countsByYear W20285440602021 @default.
• W2028544060 crossrefType "journal-article" @default.
• W2028544060 hasAuthorship W2028544060A5016783246 @default.
• W2028544060 hasAuthorship W2028544060A5031238366 @default.
• W2028544060 hasAuthorship W2028544060A5068699692 @default.
• W2028544060 hasAuthorship W2028544060A5087938172 @default.
• W2028544060 hasConcept C104317684 @default.
• W2028544060 hasConcept C126322002 @default.
• W2028544060 hasConcept C128240485 @default.
• W2028544060 hasConcept C134018914 @default.
• W2028544060 hasConcept C150194340 @default.
• W2028544060 hasConcept C170493617 @default.
• W2028544060 hasConcept C207200792 @default.
• W2028544060 hasConcept C2775960820 @default.
• W2028544060 hasConcept C2779069268 @default.
• W2028544060 hasConcept C2780689927 @default.
• W2028544060 hasConcept C2908605954 @default.
• W2028544060 hasConcept C3763915 @default.
• W2028544060 hasConcept C49039625 @default.
• W2028544060 hasConcept C55493867 @default.
• W2028544060 hasConcept C71924100 @default.
• W2028544060 hasConcept C80862487 @default.
• W2028544060 hasConcept C86803240 @default.
• W2028544060 hasConceptScore W2028544060C104317684 @default.
• W2028544060 hasConceptScore W2028544060C126322002 @default.
• W2028544060 hasConceptScore W2028544060C128240485 @default.
• W2028544060 hasConceptScore W2028544060C134018914 @default.
• W2028544060 hasConceptScore W2028544060C150194340 @default.
• W2028544060 hasConceptScore W2028544060C170493617 @default.
• W2028544060 hasConceptScore W2028544060C207200792 @default.
• W2028544060 hasConceptScore W2028544060C2775960820 @default.
• W2028544060 hasConceptScore W2028544060C2779069268 @default.
• W2028544060 hasConceptScore W2028544060C2780689927 @default.
• W2028544060 hasConceptScore W2028544060C2908605954 @default.
• W2028544060 hasConceptScore W2028544060C3763915 @default.
• W2028544060 hasConceptScore W2028544060C49039625 @default.
• W2028544060 hasConceptScore W2028544060C55493867 @default.
• W2028544060 hasConceptScore W2028544060C71924100 @default.
• W2028544060 hasConceptScore W2028544060C80862487 @default.

• next