Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028547572> ?p ?o ?g. }
- W2028547572 endingPage "647" @default.
- W2028547572 startingPage "602" @default.
- W2028547572 abstract "G protein-coupled receptors (GPCRs) are membrane proteins that traverse the plasma membrane seven times (hence, are also called 7TM receptors). The polytopic structure of GPCRs makes the folding of GPCRs difficult and complex. Indeed, many wild-type GPCRs are not folded optimally, and defects in folding are the most common cause of genetic diseases due to GPCR mutations. Both general and receptor-specific molecular chaperones aid the folding of GPCRs. Chemical chaperones have been shown to be able to correct the misfolding in mutant GPCRs, proving to be important tools for studying the structure-function relationship of GPCRs. However, their potential therapeutic value is very limited. Pharmacological chaperones (pharmacoperones) are potentially important novel therapeutics for treating genetic diseases caused by mutations in GPCR genes that resulted in misfolded mutant proteins. Pharmacoperones also increase cell surface expression of wild-type GPCRs; therefore, they could be used to treat diseases that do not harbor mutations in GPCRs. Recent studies have shown that indeed pharmacoperones work in both experimental animals and patients. High-throughput assays have been developed to identify new pharmacoperones that could be used as therapeutics for a number of endocrine and other genetic diseases." @default.
- W2028547572 created "2016-06-24" @default.
- W2028547572 creator A5043219218 @default.
- W2028547572 creator A5055634287 @default.
- W2028547572 date "2014-03-24" @default.
- W2028547572 modified "2023-10-11" @default.
- W2028547572 title "Chaperoning G Protein-Coupled Receptors: From Cell Biology to Therapeutics" @default.
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