FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028558316> ?p ?o ?g. }

• W2028558316 endingPage "187" @default.
• W2028558316 startingPage "179" @default.
• W2028558316 abstract "Concanavalin A (Con A)-induced anchorage of the major cell surface sialoglycoprotein component complex (ASGP-1/ASGP-2) was studied in 13762 rat mammary adenocarcinoma sublines with mobile (MAT-B1 subline) and immobile (MAT-C1 subline) cell surface Con A receptors. Treatment of cells, isolated microvilli, or microvillar membranes with Con A resulted in marked retention of ASGP-1 and ASGP-2, a Con A-binding protein, in cytoskeletal residues of both sublines obtained by extraction with Triton X-100 in PBS. When Con A-treated microvillar membranes were extracted with a buffer containing Triton X-100, the sialoglycoprotein complex was found associated in the residues with a transmembrane complex composed of actin, a 58,000-dalton polypeptide, and a cytoskeleton-associated glycoprotein (CAG), also a Con A-binding protein, in MAT-C1 membranes, and of actin and CAG in MAT-B1 membranes. Untreated membrane Triton residues retained very little ASGP-1/ASGP-2 complex. Association of the sialoglycomembrane complex and the transmembrane complex was also demonstrated in Con A-treated, but not untreated, microvilli by their comigration on CsCl gradients. Association of both complexes with the cytoskeleton of microvilli was shown by sucrose density gradient centrifugation. A fraction of the polymerized actin comigrated with the transmembrane complex alone in the absence of Con A and with both the transmembrane complex and the sialoglycoprotein complex in the presence of Con A. From these results we propose that anchorage of the sialoglycoprotein complex to the cytoskeleton on Con A treatment occurs by cross-linking ASGP-2, the major cell surface Con A-binding component, to CAG of the transmembrane complex, which is natively linked to the cytoskeleton via its actin component. Since Con A-induced anchorage occurs in sublines with mobile and immobile receptors, the anchorage process cannot be responsible for the differences in receptor mobility between the sublines." @default.
• W2028558316 created "2016-06-24" @default.
• W2028558316 creator A5009411101 @default.
• W2028558316 creator A5010530886 @default.
• W2028558316 creator A5023068548 @default.
• W2028558316 creator A5078359784 @default.
• W2028558316 date "1984-01-01" @default.
• W2028558316 modified "2023-09-23" @default.
• W2028558316 title "Mechanism of concanavalin A-induced anchorage of the major cell surface glycoproteins to the submembrane cytoskeleton in 13762 ascites mammary adenocarcinoma cells." @default.
• W2028558316 cites W1031262280 @default.
• W2028558316 cites W126114442 @default.
• W2028558316 cites W1550499011 @default.
• W2028558316 cites W1965773141 @default.
• W2028558316 cites W1968530847 @default.
• W2028558316 cites W1998031179 @default.
• W2028558316 cites W1998950111 @default.
• W2028558316 cites W2001771907 @default.
• W2028558316 cites W2007524790 @default.
• W2028558316 cites W2008536447 @default.
• W2028558316 cites W2019675508 @default.
• W2028558316 cites W2022954330 @default.
• W2028558316 cites W2025371958 @default.
• W2028558316 cites W2032552957 @default.
• W2028558316 cites W2052741984 @default.
• W2028558316 cites W2058278808 @default.
• W2028558316 cites W2058381769 @default.
• W2028558316 cites W2059697726 @default.
• W2028558316 cites W2062051274 @default.
• W2028558316 cites W2082781248 @default.
• W2028558316 cites W2090962190 @default.
• W2028558316 cites W2094565386 @default.
• W2028558316 cites W2145054922 @default.
• W2028558316 cites W2158692971 @default.
• W2028558316 cites W55811972 @default.
• W2028558316 cites W95923994 @default.
• W2028558316 doi "https://doi.org/10.1083/jcb.98.1.179" @default.
• W2028558316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2113011" @default.
• W2028558316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6538571" @default.
• W2028558316 hasPublicationYear "1984" @default.
• W2028558316 type Work @default.
• W2028558316 sameAs 2028558316 @default.
• W2028558316 citedByCount "27" @default.
• W2028558316 countsByYear W20285583162022 @default.
• W2028558316 crossrefType "journal-article" @default.
• W2028558316 hasAuthorship W2028558316A5009411101 @default.
• W2028558316 hasAuthorship W2028558316A5010530886 @default.
• W2028558316 hasAuthorship W2028558316A5023068548 @default.
• W2028558316 hasAuthorship W2028558316A5078359784 @default.
• W2028558316 hasBestOaLocation W20285583161 @default.
• W2028558316 hasConcept C108625454 @default.
• W2028558316 hasConcept C125705527 @default.
• W2028558316 hasConcept C142669718 @default.
• W2028558316 hasConcept C1491633281 @default.
• W2028558316 hasConcept C153911025 @default.
• W2028558316 hasConcept C170493617 @default.
• W2028558316 hasConcept C20418707 @default.
• W2028558316 hasConcept C24530287 @default.
• W2028558316 hasConcept C2776178622 @default.
• W2028558316 hasConcept C2777459641 @default.
• W2028558316 hasConcept C55493867 @default.
• W2028558316 hasConcept C86803240 @default.
• W2028558316 hasConcept C95444343 @default.
• W2028558316 hasConceptScore W2028558316C108625454 @default.
• W2028558316 hasConceptScore W2028558316C125705527 @default.
• W2028558316 hasConceptScore W2028558316C142669718 @default.
• W2028558316 hasConceptScore W2028558316C1491633281 @default.
• W2028558316 hasConceptScore W2028558316C153911025 @default.
• W2028558316 hasConceptScore W2028558316C170493617 @default.
• W2028558316 hasConceptScore W2028558316C20418707 @default.
• W2028558316 hasConceptScore W2028558316C24530287 @default.
• W2028558316 hasConceptScore W2028558316C2776178622 @default.
• W2028558316 hasConceptScore W2028558316C2777459641 @default.
• W2028558316 hasConceptScore W2028558316C55493867 @default.
• W2028558316 hasConceptScore W2028558316C86803240 @default.
• W2028558316 hasConceptScore W2028558316C95444343 @default.
• W2028558316 hasIssue "1" @default.
• W2028558316 hasLocation W20285583161 @default.
• W2028558316 hasLocation W20285583162 @default.
• W2028558316 hasLocation W20285583163 @default.
• W2028558316 hasLocation W20285583164 @default.
• W2028558316 hasOpenAccess W2028558316 @default.
• W2028558316 hasPrimaryLocation W20285583161 @default.
• W2028558316 hasRelatedWork W113776368 @default.
• W2028558316 hasRelatedWork W1991430715 @default.
• W2028558316 hasRelatedWork W2037078351 @default.
• W2028558316 hasRelatedWork W2039495782 @default.
• W2028558316 hasRelatedWork W2219364886 @default.
• W2028558316 hasRelatedWork W2271407082 @default.
• W2028558316 hasRelatedWork W2346385215 @default.
• W2028558316 hasRelatedWork W2971620622 @default.
• W2028558316 hasRelatedWork W3183741787 @default.
• W2028558316 hasRelatedWork W4220942634 @default.
• W2028558316 hasVolume "98" @default.
• W2028558316 isParatext "false" @default.
• W2028558316 isRetracted "false" @default.
• W2028558316 magId "2028558316" @default.
• W2028558316 workType "article" @default.