FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028560023> ?p ?o ?g. }

• W2028560023 endingPage "484" @default.
• W2028560023 startingPage "481" @default.
• W2028560023 abstract "Five AZT (azidothymidine) prodrugs conjugated with the 1-adamantane moiety via an ester bond were synthesized to improve the transport of AZT into the central nervous system (CNS). In in vitro degradation studies with rat and human plasma, it was demonstrated that the prodrugs were degradated enzymatically and converted quantitatively to their parent drug, AZT. As assessed by octanol–buffer partitioning, the prodrugs were much more lipophilic than AZT and were expected to penetrate the blood–brain barrier (BBB) readily. In in vivo studies, in which the prodrugs were administered intravenously to rat, the prodrugs in brain tissue were detected at 7–18 times higher concentrations than AZT in spite of the negligible amount of the prodrug in the cerebrospinal fluid. These results indicate that the introduction to AZT of the 1-adamantane moiety results in the enhancement of the BBB penetration. This pharmaceutical approach would be beneficial for the efficient treatment of the CNS infection by human immunodeficiency virus." @default.
• W2028560023 created "2016-06-24" @default.
• W2028560023 creator A5003027751 @default.
• W2028560023 creator A5025098431 @default.
• W2028560023 creator A5049833581 @default.
• W2028560023 creator A5060889663 @default.
• W2028560023 creator A5063433113 @default.
• W2028560023 creator A5064886807 @default.
• W2028560023 creator A5065753368 @default.
• W2028560023 creator A5073630328 @default.
• W2028560023 creator A5078164498 @default.
• W2028560023 date "1994-04-01" @default.
• W2028560023 modified "2023-09-26" @default.
• W2028560023 title "Adamantane as a Brain-Directed Drug Carrier for Poorly Absorbed Drug. 2. AZT Derivatives Conjugated with the 1-Adamantane Moiety" @default.
• W2028560023 cites W1974905296 @default.
• W2028560023 cites W1979485830 @default.
• W2028560023 cites W1982796443 @default.
• W2028560023 cites W1992756089 @default.
• W2028560023 cites W2005379867 @default.
• W2028560023 cites W2012473563 @default.
• W2028560023 cites W2026588653 @default.
• W2028560023 cites W2043371596 @default.
• W2028560023 cites W2044074470 @default.
• W2028560023 cites W2054621963 @default.
• W2028560023 cites W2055412931 @default.
• W2028560023 cites W2089336861 @default.
• W2028560023 cites W2094793927 @default.
• W2028560023 cites W2110411605 @default.
• W2028560023 cites W2113928960 @default.
• W2028560023 cites W2160871721 @default.
• W2028560023 cites W2312778470 @default.
• W2028560023 cites W2322092063 @default.
• W2028560023 cites W2327331335 @default.
• W2028560023 cites W2951262406 @default.
• W2028560023 doi "https://doi.org/10.1002/jps.2600830407" @default.
• W2028560023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8046599" @default.
• W2028560023 hasPublicationYear "1994" @default.
• W2028560023 type Work @default.
• W2028560023 sameAs 2028560023 @default.
• W2028560023 citedByCount "63" @default.
• W2028560023 countsByYear W20285600232012 @default.
• W2028560023 countsByYear W20285600232013 @default.
• W2028560023 countsByYear W20285600232015 @default.
• W2028560023 countsByYear W20285600232016 @default.
• W2028560023 countsByYear W20285600232017 @default.
• W2028560023 countsByYear W20285600232018 @default.
• W2028560023 countsByYear W20285600232020 @default.
• W2028560023 countsByYear W20285600232021 @default.
• W2028560023 countsByYear W20285600232022 @default.
• W2028560023 crossrefType "journal-article" @default.
• W2028560023 hasAuthorship W2028560023A5003027751 @default.
• W2028560023 hasAuthorship W2028560023A5025098431 @default.
• W2028560023 hasAuthorship W2028560023A5049833581 @default.
• W2028560023 hasAuthorship W2028560023A5060889663 @default.
• W2028560023 hasAuthorship W2028560023A5063433113 @default.
• W2028560023 hasAuthorship W2028560023A5064886807 @default.
• W2028560023 hasAuthorship W2028560023A5065753368 @default.
• W2028560023 hasAuthorship W2028560023A5073630328 @default.
• W2028560023 hasAuthorship W2028560023A5078164498 @default.
• W2028560023 hasConcept C108215921 @default.
• W2028560023 hasConcept C112613896 @default.
• W2028560023 hasConcept C112705442 @default.
• W2028560023 hasConcept C126322002 @default.
• W2028560023 hasConcept C150903083 @default.
• W2028560023 hasConcept C159047783 @default.
• W2028560023 hasConcept C178790620 @default.
• W2028560023 hasConcept C185592680 @default.
• W2028560023 hasConcept C202751555 @default.
• W2028560023 hasConcept C207001950 @default.
• W2028560023 hasConcept C2776568683 @default.
• W2028560023 hasConcept C2778402981 @default.
• W2028560023 hasConcept C2779556047 @default.
• W2028560023 hasConcept C2780035454 @default.
• W2028560023 hasConcept C2780216070 @default.
• W2028560023 hasConcept C2780727368 @default.
• W2028560023 hasConcept C3013748606 @default.
• W2028560023 hasConcept C521977710 @default.
• W2028560023 hasConcept C529278444 @default.
• W2028560023 hasConcept C55493867 @default.
• W2028560023 hasConcept C71240020 @default.
• W2028560023 hasConcept C71924100 @default.
• W2028560023 hasConcept C86803240 @default.
• W2028560023 hasConcept C98274493 @default.
• W2028560023 hasConceptScore W2028560023C108215921 @default.
• W2028560023 hasConceptScore W2028560023C112613896 @default.
• W2028560023 hasConceptScore W2028560023C112705442 @default.
• W2028560023 hasConceptScore W2028560023C126322002 @default.
• W2028560023 hasConceptScore W2028560023C150903083 @default.
• W2028560023 hasConceptScore W2028560023C159047783 @default.
• W2028560023 hasConceptScore W2028560023C178790620 @default.
• W2028560023 hasConceptScore W2028560023C185592680 @default.
• W2028560023 hasConceptScore W2028560023C202751555 @default.
• W2028560023 hasConceptScore W2028560023C207001950 @default.
• W2028560023 hasConceptScore W2028560023C2776568683 @default.
• W2028560023 hasConceptScore W2028560023C2778402981 @default.
• W2028560023 hasConceptScore W2028560023C2779556047 @default.
• W2028560023 hasConceptScore W2028560023C2780035454 @default.
• W2028560023 hasConceptScore W2028560023C2780216070 @default.

• next