FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028565533> ?p ?o ?g. }

• W2028565533 endingPage "147" @default.
• W2028565533 startingPage "131" @default.
• W2028565533 abstract "We have previously reported chronic low-intensity interval exercise training attenuates fibrosis, impaired cardiac mitochondrial function, and coronary vascular dysfunction in miniature swine with left ventricular (LV) hypertrophy (Emter CA, Baines CP. Am J Physiol Heart Circ Physiol 299: H1348-H1356, 2010; Emter CA, et al. Am J Physiol Heart Circ Physiol 301: H1687-H1694, 2011). The purpose of this study was to test two hypotheses: 1) chronic low-intensity interval training preserves normal myocardial oxygen supply/demand balance; and 2) training-dependent attenuation of LV fibrotic remodeling improves diastolic function in aortic-banded sedentary, exercise-trained (HF-TR), and control sedentary male Yucatan miniature swine displaying symptoms of heart failure with preserved ejection fraction. Pressure-volume loops, coronary blood flow, and two-dimensional speckle tracking ultrasound were utilized in vivo under conditions of increasing peripheral mean arterial pressure and β-adrenergic stimulation 6 mo postsurgery to evaluate cardiac function. Normal diastolic function in HF-TR animals was characterized by prevention of increased time constant of isovolumic relaxation, normal LV untwisting rate, and enhanced apical circumferential and radial strain rate. Reduced fibrosis, normal matrix metalloproteinase-2 and tissue inhibitors of metalloproteinase-4 mRNA expression, and increased collagen III isoform mRNA levels (P < 0.05) accompanied improved diastolic function following chronic training. Exercise-dependent improvements in coronary blood flow for a given myocardial oxygen consumption (P < 0.05) and cardiac efficiency (stroke work to myocardial oxygen consumption, P < 0.05) were associated with preserved contractile reserve. LV hypertrophy in HF-TR animals was associated with increased activation of Akt and preservation of activated JNK/SAPK. In conclusion, chronic low-intensity interval exercise training attenuates diastolic impairment by promoting compliant extracellular matrix fibrotic components and preserving extracellular matrix regulatory mechanisms, preserves myocardial oxygen balance, and promotes a physiological molecular hypertrophic signaling phenotype in a large animal model resembling heart failure with preserved ejection fraction." @default.
• W2028565533 created "2016-06-24" @default.
• W2028565533 creator A5018093465 @default.
• W2028565533 creator A5019570304 @default.
• W2028565533 creator A5031818852 @default.
• W2028565533 creator A5040693498 @default.
• W2028565533 creator A5060841857 @default.
• W2028565533 creator A5066205800 @default.
• W2028565533 creator A5067429117 @default.
• W2028565533 date "2013-01-01" @default.
• W2028565533 modified "2023-10-18" @default.
• W2028565533 title "Heart failure with preserved ejection fraction: chronic low-intensity interval exercise training preserves myocardial O₂ balance and diastolic function" @default.
• W2028565533 cites W1243095227 @default.
• W2028565533 cites W1524945657 @default.
• W2028565533 cites W1570914098 @default.
• W2028565533 cites W1615746675 @default.
• W2028565533 cites W16158435 @default.
• W2028565533 cites W1718077751 @default.
• W2028565533 cites W1824633525 @default.
• W2028565533 cites W1857390120 @default.
• W2028565533 cites W1873535914 @default.
• W2028565533 cites W1969639902 @default.
• W2028565533 cites W1979460560 @default.
• W2028565533 cites W1983102904 @default.
• W2028565533 cites W1989524545 @default.
• W2028565533 cites W1989950796 @default.
• W2028565533 cites W1994267209 @default.
• W2028565533 cites W1994704174 @default.
• W2028565533 cites W1996500970 @default.
• W2028565533 cites W2022534074 @default.
• W2028565533 cites W2027218466 @default.
• W2028565533 cites W2028982689 @default.
• W2028565533 cites W2030768343 @default.
• W2028565533 cites W2031217240 @default.
• W2028565533 cites W2041714371 @default.
• W2028565533 cites W2042076829 @default.
• W2028565533 cites W2049396553 @default.
• W2028565533 cites W2059973619 @default.
• W2028565533 cites W2060072866 @default.
• W2028565533 cites W2061357761 @default.
• W2028565533 cites W2062283925 @default.
• W2028565533 cites W2063762948 @default.
• W2028565533 cites W2064046486 @default.
• W2028565533 cites W2066340356 @default.
• W2028565533 cites W2068905608 @default.
• W2028565533 cites W2080053058 @default.
• W2028565533 cites W2081014727 @default.
• W2028565533 cites W2081590661 @default.
• W2028565533 cites W2094138142 @default.
• W2028565533 cites W2097531156 @default.
• W2028565533 cites W2097597389 @default.
• W2028565533 cites W2098587086 @default.
• W2028565533 cites W2100810762 @default.
• W2028565533 cites W2101637339 @default.
• W2028565533 cites W2101688082 @default.
• W2028565533 cites W2105891966 @default.
• W2028565533 cites W2107277218 @default.
• W2028565533 cites W2108899429 @default.
• W2028565533 cites W2108899989 @default.
• W2028565533 cites W2110324432 @default.
• W2028565533 cites W2116266881 @default.
• W2028565533 cites W2116798343 @default.
• W2028565533 cites W2117220835 @default.
• W2028565533 cites W2118568417 @default.
• W2028565533 cites W2118634943 @default.
• W2028565533 cites W2119224327 @default.
• W2028565533 cites W2119752929 @default.
• W2028565533 cites W2120580408 @default.
• W2028565533 cites W2120601131 @default.
• W2028565533 cites W2125599236 @default.
• W2028565533 cites W2126488412 @default.
• W2028565533 cites W2127851750 @default.
• W2028565533 cites W2129094446 @default.
• W2028565533 cites W2129640029 @default.
• W2028565533 cites W2130647056 @default.
• W2028565533 cites W2131050684 @default.
• W2028565533 cites W2145950740 @default.
• W2028565533 cites W2148075660 @default.
• W2028565533 cites W2151591330 @default.
• W2028565533 cites W2153177273 @default.
• W2028565533 cites W2153195779 @default.
• W2028565533 cites W2158550922 @default.
• W2028565533 cites W2160222875 @default.
• W2028565533 cites W2160879918 @default.
• W2028565533 cites W2162799710 @default.
• W2028565533 cites W2162803475 @default.
• W2028565533 cites W2165009569 @default.
• W2028565533 cites W2168915540 @default.
• W2028565533 cites W2169961307 @default.
• W2028565533 cites W2170605369 @default.
• W2028565533 cites W2171415584 @default.
• W2028565533 cites W2171515161 @default.
• W2028565533 cites W2764148593 @default.
• W2028565533 cites W4243622324 @default.
• W2028565533 cites W4249124981 @default.
• W2028565533 cites W954944586 @default.
• W2028565533 cites W98344349 @default.
• W2028565533 doi "https://doi.org/10.1152/japplphysiol.01059.2012" @default.

• next