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- W2028573804 abstract "Alzheimer's disease (AD) is the most common form of dementia. Severe memory loss, confusion, and impaired cognitive abilities characterize AD. It was only a century after Alzheimer's discovery that scientists were able to shed light on the mystery of its cause, but AD has also become a globally important health issue and the treatment of AD is a challenge for modern medicine. At present, there are five drugs approved in the United States for the treatment of AD, namely, donepezil, galantamine, rivastigmine, and tacrine (which are all cholinesterase inhibitors); and memantine (which is a glutamate receptor antagonist). However, these drugs show only modest effects on AD patients. Thus, new investigations are necessary for pharmacological development in AD. This brief review focuses on new studies that demonstrate the link between epigenetics and AD, and explores the possibility that insomnia may be one factor that effects AD." @default.
- W2028573804 created "2016-06-24" @default.
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- W2028573804 date "2007-10-01" @default.
- W2028573804 modified "2023-10-17" @default.
- W2028573804 title "P.1.c.035 Behavioral and pharmacological changes after neonatal nitric oxide inhibition: a model of negative symptoms" @default.
- W2028573804 doi "https://doi.org/10.1016/s0924-977x(07)70359-0" @default.
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