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• W2028577012 abstract "The role of Ca2+ in protein secretion from rat exocrine pancreas and the effect of cyclic AMP and its dibutyryl analogue on the secretory process were studied. The secretory response of the tissue to an optimal concentration of carbachol was potentiated by dibutyryl cyclic AMP to an extent greated than the sum of the individual effects of the two agents, suggesting that the nucleotide stimulated a rate limiting step(s) in the secretion process. The secretory effects of carbachol and dibutyryl cyclic AMP, alone or in combination were Ca2+ dependent. Mn2+ inhibited the secretory response to carbachol and carbachol plus dibutyryl cyclic AMP but did not significantly alter the response to the nucleotide alone. Repeated stimulation of pancreas fragments in the absence of added Ca2+ let to a progressive decline in secretory response; the rate of decline was much more rapid when the stimulus was carbachol than when carbachol plus dibutyryl cyclic AMP was used. The response to dibutyryl cyclic AMP alone was not affected by this procedure. The readdition of Ca2+ to the incubation medium after a period of stimulation in the absence of Ca2+ restored the response to carbachol plus dibutyryl cyclic AMP but did not restore the response to carbachol. These data suggest that Ca2+ is essential for carbachol stimulated protein secretion. Botj extracellular and intracellular Ca2+ may be utilized and this ion is a limiting factor in the secretion process. Dibutyryl cyclic AMP may not potentiate the secretory effect of carbachol by its ability to mobilize and conserve intracellular Ca2+ for utilization in the secretion process." @default.
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• W2028577012 date "1972-10-01" @default.
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• W2028577012 title "Role of Ca2+ and cyclic AMP in protein secretion from rat exocrine pancreas" @default.
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• W2028577012 doi "https://doi.org/10.1016/0304-4165(72)90178-x" @default.
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