FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028577811> ?p ?o ?g. }

• W2028577811 endingPage "407" @default.
• W2028577811 startingPage "399" @default.
• W2028577811 abstract "We present evidence here that abundantly expressed b-catenin-triggered NF-kB-dependent upregulation of inducible nitric oxide synthase(iNOS) found in hepatoma Mahlavu cells (RT-resistant variant designated as RR-Mal), but not in Hep 3B cells (RT-sensitive variant designated as RS-3B) is a key element contribrting to the radioresisitance through the activation of two prominent radioprotective pathways. First, high iNOS expression found in RR-Mal, but not in RS-3B cells was found to perturb calcium homeostasis that triggered ER stress response leading to the overproduction of ER chaperone GRP-78 via robust generation of cleaved ATF-6a (50 kDa) subunits and their nuclear translocation. Meanwhile, both abundantly expressed NF-κB and COX-2 found in RR-Mal cells could also provoke an increased production of PGE2 resulting in robust production of Bcl-2. Interestingly, when RR-Mal cells were treated with PDTC (a NF-κB inhibitor) or celecoxib (a COX-2 inhibitor), a concentration-dependent downregulation of Bcl-2 could be demonstrated implying that Bcl-2 overexpression was indeed mediated through NF-κB/Cox-2/PGE2 pathway. Importantly, we also unveiled that siRNA-mediated silencing of survivin in RR-Mal cells could result in a concomitant downregulation of GRP-78 due to a severe inhibition of ATF-6a (50 kDa) expression. Taken together, our data demonstrate that constitutively overexpressed b-catenin/NF-κB/iNOS and NF-κB/COX-2/PGE2 pathways that overproducing GRP-78, survivin and Bcl-2 expressions are responsible for radioresistance acquisition in RR-Mal cells. Thus, both pathways could be served as potential targets for overcoming radioresistance." @default.
• W2028577811 created "2016-06-24" @default.
• W2028577811 creator A5009782444 @default.
• W2028577811 creator A5041948477 @default.
• W2028577811 creator A5045249181 @default.
• W2028577811 creator A5045352897 @default.
• W2028577811 creator A5053323336 @default.
• W2028577811 creator A5070536242 @default.
• W2028577811 creator A5077299038 @default.
• W2028577811 date "2013-01-01" @default.
• W2028577811 modified "2023-09-28" @default.
• W2028577811 title "Constitutive Overexpression of Bcl-2, Survivin and ER Stress Chaperone GRP-78 Confers Intrinsic Radioresistance in Human Hepatocellular Carcinoma Cells: Insight into the Mechanistic Pathways Involved" @default.
• W2028577811 cites W1507219966 @default.
• W2028577811 cites W1572504392 @default.
• W2028577811 cites W1969531716 @default.
• W2028577811 cites W1972113997 @default.
• W2028577811 cites W1973806975 @default.
• W2028577811 cites W1975906321 @default.
• W2028577811 cites W1978188500 @default.
• W2028577811 cites W1981938979 @default.
• W2028577811 cites W1983700628 @default.
• W2028577811 cites W1996096140 @default.
• W2028577811 cites W2006298485 @default.
• W2028577811 cites W2010831478 @default.
• W2028577811 cites W2020830322 @default.
• W2028577811 cites W2030251416 @default.
• W2028577811 cites W2032592355 @default.
• W2028577811 cites W2044843189 @default.
• W2028577811 cites W2050532007 @default.
• W2028577811 cites W2053663898 @default.
• W2028577811 cites W2071102786 @default.
• W2028577811 cites W2074452470 @default.
• W2028577811 cites W2084806223 @default.
• W2028577811 cites W2093477714 @default.
• W2028577811 cites W2104008913 @default.
• W2028577811 cites W2105329481 @default.
• W2028577811 cites W2106371645 @default.
• W2028577811 cites W2106787323 @default.
• W2028577811 cites W2111791735 @default.
• W2028577811 cites W2115262835 @default.
• W2028577811 cites W2115538252 @default.
• W2028577811 cites W2143981899 @default.
• W2028577811 cites W2149169850 @default.
• W2028577811 cites W2282054059 @default.
• W2028577811 doi "https://doi.org/10.4236/jct.2013.42a048" @default.
• W2028577811 hasPublicationYear "2013" @default.
• W2028577811 type Work @default.
• W2028577811 sameAs 2028577811 @default.
• W2028577811 citedByCount "3" @default.
• W2028577811 countsByYear W20285778112016 @default.
• W2028577811 countsByYear W20285778112017 @default.
• W2028577811 countsByYear W20285778112018 @default.
• W2028577811 crossrefType "journal-article" @default.
• W2028577811 hasAuthorship W2028577811A5009782444 @default.
• W2028577811 hasAuthorship W2028577811A5041948477 @default.
• W2028577811 hasAuthorship W2028577811A5045249181 @default.
• W2028577811 hasAuthorship W2028577811A5045352897 @default.
• W2028577811 hasAuthorship W2028577811A5053323336 @default.
• W2028577811 hasAuthorship W2028577811A5070536242 @default.
• W2028577811 hasAuthorship W2028577811A5077299038 @default.
• W2028577811 hasBestOaLocation W20285778111 @default.
• W2028577811 hasConcept C104317684 @default.
• W2028577811 hasConcept C119056186 @default.
• W2028577811 hasConcept C127561419 @default.
• W2028577811 hasConcept C153911025 @default.
• W2028577811 hasConcept C185592680 @default.
• W2028577811 hasConcept C190283241 @default.
• W2028577811 hasConcept C19106626 @default.
• W2028577811 hasConcept C203014093 @default.
• W2028577811 hasConcept C2775975398 @default.
• W2028577811 hasConcept C2777730290 @default.
• W2028577811 hasConcept C502942594 @default.
• W2028577811 hasConcept C54355233 @default.
• W2028577811 hasConcept C55493867 @default.
• W2028577811 hasConcept C58962609 @default.
• W2028577811 hasConcept C62478195 @default.
• W2028577811 hasConcept C81885089 @default.
• W2028577811 hasConcept C86803240 @default.
• W2028577811 hasConcept C95444343 @default.
• W2028577811 hasConceptScore W2028577811C104317684 @default.
• W2028577811 hasConceptScore W2028577811C119056186 @default.
• W2028577811 hasConceptScore W2028577811C127561419 @default.
• W2028577811 hasConceptScore W2028577811C153911025 @default.
• W2028577811 hasConceptScore W2028577811C185592680 @default.
• W2028577811 hasConceptScore W2028577811C190283241 @default.
• W2028577811 hasConceptScore W2028577811C19106626 @default.
• W2028577811 hasConceptScore W2028577811C203014093 @default.
• W2028577811 hasConceptScore W2028577811C2775975398 @default.
• W2028577811 hasConceptScore W2028577811C2777730290 @default.
• W2028577811 hasConceptScore W2028577811C502942594 @default.
• W2028577811 hasConceptScore W2028577811C54355233 @default.
• W2028577811 hasConceptScore W2028577811C55493867 @default.
• W2028577811 hasConceptScore W2028577811C58962609 @default.
• W2028577811 hasConceptScore W2028577811C62478195 @default.
• W2028577811 hasConceptScore W2028577811C81885089 @default.
• W2028577811 hasConceptScore W2028577811C86803240 @default.
• W2028577811 hasConceptScore W2028577811C95444343 @default.
• W2028577811 hasIssue "02" @default.

• next