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- W2028578729 abstract "We demonstrate that a spatial and temporal analysis of subclinical hyperemia reliably predicts specific areas at high riskfor skin tumor development during photocarcinogenesis. To determine detailed spatiotemporal patterns of inflammatoryangiogenesis foci in a relatively large area, we developed a mesoscopic (between microscopic and macroscopic) imagingapproach. This method relies on our earlier finding that the combination of a spectral analysis of hemoglobin withdiffuse-light-suppressed imaging can increase the image resolution, contrast and penetration depth to visualizemicrovasculature Hgb content in the large tissue area. In our recent study, SKH1 hairless albino mice were irradiatedfor 10 weeks with a carcinogen dose of UVB. Using our newly developed mesoscopic imaging methods, we imagedthe mice over 20 - 30 weeks after stopping UVB, and excised hyperemic/non-hyperemic areas at several different timepoints.We show that persistent hyperemic foci can predict future tumor formation. In particular, our imaging approachallows us to assess the spatial and temporal extent of subclinical inflammatory foci, which in turn can predict sites offuture overlying tumor formation. In addition, although COX-2 inhibitors are known to suppress skin cancerdevelopment in humans, it remains unclear whether the chemopreventive activity of COX-2 inhibitors are chieflyattributable to their anti-inflammatory effects. Our study provides evidence that subclinical subepithelial inflammatoryfoci occur prior to overt tumor formation, and that these areas are highly predictive for future tumor formation, thatcelecoxib’s ability to suppress tumorigenesis is tightly linked to its ability to reduce the area of subclinical inflammatoryfoci." @default.
- W2028578729 created "2016-06-24" @default.
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- W2028578729 date "2014-03-04" @default.
- W2028578729 modified "2023-09-23" @default.
- W2028578729 title "Tumor site prediction using spatiotemporal detection of subclinical hyperemia in experimental photocarcinogenesis" @default.
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- W2028578729 doi "https://doi.org/10.1117/12.2040891" @default.
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