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• W2028585080 abstract "Using the X-ray crystal structure of the inhibitor 1 complexed to HIV-1 protease, a new series of HIV-1 protease inhibitors was developed incorporating substituted isophthalic acid derivatives as amino acid surrogates. Through iterative structure-based design, the lead compound 2 was optimized to produce a variety of non-peptide HIV-1 protease inhibitors with significant antiviral activity. In contrast to 1, several members of this series exhibit significant oral absorption in animals." @default.
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• W2028585080 date "1995-04-01" @default.
• W2028585080 modified "2023-10-03" @default.
• W2028585080 title "Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease" @default.
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• W2028585080 doi "https://doi.org/10.1016/0960-894x(95)00102-y" @default.
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