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• W2028590145 endingPage "1364" @default.
• W2028590145 startingPage "1354" @default.
• W2028590145 abstract "The apicomplexan parasite Cryptosporidium parvum, the agent of cryptosporidiosis, primarily infects and reproduces in enterocytes. Interferon (IFN)-γ is important for early control of the infection and acts directly on enterocytes to inhibit parasite development, although complete inhibition is not obtained. Addressing this latter observation, an investigation was made of the modulatory effect of C. parvum infection on IFN-γ-dependent enterocyte gene expression. Initial studies showed that IFN-γ-induced expression of indoleamine 2, 3 dioxygenase (IDO) mRNA and protein in CMT-93 cells was abrogated by C. parvum infection. Infection also inhibited IDO expression by the human enterocyte cell lines HT29 and Caco-2. Expression of IFN-γ-inducible genes important in the development of immune responses, including major histocompatibility complex class II and CIITA, was also inhibited by the parasite. Investigating a possible mechanism for these findings, it was shown that infection caused depletion of STAT1α protein, a key transcription factor in IFN-γ signalling. These findings indicate C. parvum interferes with IFN-γ-dependent gene expression in enterocytes and suggest this activity could be a novel immuno-evasive strategy employed by the parasite." @default.
• W2028590145 created "2016-06-24" @default.
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• W2028590145 date "2009-09-01" @default.
• W2028590145 modified "2023-10-18" @default.
• W2028590145 title "Dysregulation of interferon-γ-mediated signalling pathway in intestinal epithelial cells by<i>Cryptosporidium parvum</i>infection" @default.
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• W2028590145 doi "https://doi.org/10.1111/j.1462-5822.2009.01336.x" @default.
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