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• W2028592543 abstract "Telomeres in mammals and plants are protected by the terminal t loop structure, the formation of which parallels the first steps of intrachromatid homologous recombination (HR). Under some circumstances, cells can also utilize an HR-based mechanism (alternative lengthening of telomeres [ALT]) as a back-up pathway for telomere maintenance. We have found that the Ku70/80 heterodimer, a central nonhomologous end-joining DNA repair factor, inhibits engagement of ALT in Arabidopsis telomerase-negative cells. To further assess HR activities at telomeres, we have developed a sensitive assay for detecting extrachromosomal telomeric circles (t circles) that may arise from t loop resolution and aberrant HR. We show that Ku70/80 specifically inhibits circle formation at telomeres, but not at centromeric and rDNA repeats. Ku inactivation results in increased formation of t circles that represent approximately 4% of total telomeric DNA. However, telomeres in ku mutants are fully functional, indicating that telomerase efficiently heals ongoing terminal deletions arising from excision of the t circles." @default.
• W2028592543 created "2016-06-24" @default.
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• W2028592543 date "2007-07-01" @default.
• W2028592543 modified "2023-10-16" @default.
• W2028592543 title "Ku Suppresses Formation of Telomeric Circles and Alternative Telomere Lengthening in Arabidopsis" @default.
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• W2028592543 doi "https://doi.org/10.1016/j.molcel.2007.05.025" @default.
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