Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028595890> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2028595890 endingPage "437" @default.
- W2028595890 startingPage "433" @default.
- W2028595890 abstract "Lidocaine kinetics were examined during continuous infusions in five healthy subjects using stable isotope lidocaine labeled with two deuterium atoms. During phase 1, lidocaine and stable isotope lidocaine (50 mg IV each) were given as a bolus to confirm that the two species were kinetically identical. Phase 2 consisted of a long-term (30 hr) lidocaine infusion designed to produce a steady-state concentration equal to 1.5 μg/ml. Twenty-four hours into the infusion, stable isotope lidocaine (50 mg) was given as an intravenous bolus and kinetic parameters were calculated. Phase 3 differed from phase 2 in that the target steady-state lidocaine concentration was 4 μg/ml and the stable isotope lidocaine dose was reduced to 40 mg. A gas chromatograph–mass spectrometer was used to determine lidocaine and stable isotope lidocaine serum concentrations. Compared to phase 1, clearance decreased (P < 0.05) and half-life increased (P < 0.025) during phases 2 and 3. The volume of distribution at steady-state remained constant during all three phases. Lidocaine cumulated in serum during long-term infusions in all five subjects; repeated decreases in infusion rate were necessary to avoid exceeding desired target concentrations in phases 2 and 3. Clinical Pharmacology and Therapeutics (1982) 31, 433–437; doi:10.1038/clpt.1982.56" @default.
- W2028595890 created "2016-06-24" @default.
- W2028595890 creator A5006856540 @default.
- W2028595890 creator A5013177618 @default.
- W2028595890 creator A5017866680 @default.
- W2028595890 creator A5045557052 @default.
- W2028595890 creator A5050638946 @default.
- W2028595890 creator A5086348275 @default.
- W2028595890 creator A5087288886 @default.
- W2028595890 date "1982-04-01" @default.
- W2028595890 modified "2023-10-10" @default.
- W2028595890 title "Influence of long-term infusions on lidocaine kinetics" @default.
- W2028595890 doi "https://doi.org/10.1038/clpt.1982.56" @default.
- W2028595890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7060324" @default.
- W2028595890 hasPublicationYear "1982" @default.
- W2028595890 type Work @default.
- W2028595890 sameAs 2028595890 @default.
- W2028595890 citedByCount "50" @default.
- W2028595890 countsByYear W20285958902012 @default.
- W2028595890 countsByYear W20285958902018 @default.
- W2028595890 countsByYear W20285958902019 @default.
- W2028595890 countsByYear W20285958902021 @default.
- W2028595890 crossrefType "journal-article" @default.
- W2028595890 hasAuthorship W2028595890A5006856540 @default.
- W2028595890 hasAuthorship W2028595890A5013177618 @default.
- W2028595890 hasAuthorship W2028595890A5017866680 @default.
- W2028595890 hasAuthorship W2028595890A5045557052 @default.
- W2028595890 hasAuthorship W2028595890A5050638946 @default.
- W2028595890 hasAuthorship W2028595890A5086348275 @default.
- W2028595890 hasAuthorship W2028595890A5087288886 @default.
- W2028595890 hasConcept C112705442 @default.
- W2028595890 hasConcept C121332964 @default.
- W2028595890 hasConcept C139254425 @default.
- W2028595890 hasConcept C141071460 @default.
- W2028595890 hasConcept C147789679 @default.
- W2028595890 hasConcept C148898269 @default.
- W2028595890 hasConcept C164304813 @default.
- W2028595890 hasConcept C185592680 @default.
- W2028595890 hasConcept C2780149897 @default.
- W2028595890 hasConcept C3020190219 @default.
- W2028595890 hasConcept C3941253 @default.
- W2028595890 hasConcept C42219234 @default.
- W2028595890 hasConcept C43376680 @default.
- W2028595890 hasConcept C43617362 @default.
- W2028595890 hasConcept C62520636 @default.
- W2028595890 hasConcept C71924100 @default.
- W2028595890 hasConcept C8171440 @default.
- W2028595890 hasConcept C98274493 @default.
- W2028595890 hasConceptScore W2028595890C112705442 @default.
- W2028595890 hasConceptScore W2028595890C121332964 @default.
- W2028595890 hasConceptScore W2028595890C139254425 @default.
- W2028595890 hasConceptScore W2028595890C141071460 @default.
- W2028595890 hasConceptScore W2028595890C147789679 @default.
- W2028595890 hasConceptScore W2028595890C148898269 @default.
- W2028595890 hasConceptScore W2028595890C164304813 @default.
- W2028595890 hasConceptScore W2028595890C185592680 @default.
- W2028595890 hasConceptScore W2028595890C2780149897 @default.
- W2028595890 hasConceptScore W2028595890C3020190219 @default.
- W2028595890 hasConceptScore W2028595890C3941253 @default.
- W2028595890 hasConceptScore W2028595890C42219234 @default.
- W2028595890 hasConceptScore W2028595890C43376680 @default.
- W2028595890 hasConceptScore W2028595890C43617362 @default.
- W2028595890 hasConceptScore W2028595890C62520636 @default.
- W2028595890 hasConceptScore W2028595890C71924100 @default.
- W2028595890 hasConceptScore W2028595890C8171440 @default.
- W2028595890 hasConceptScore W2028595890C98274493 @default.
- W2028595890 hasIssue "4" @default.
- W2028595890 hasLocation W20285958901 @default.
- W2028595890 hasLocation W20285958902 @default.
- W2028595890 hasOpenAccess W2028595890 @default.
- W2028595890 hasPrimaryLocation W20285958901 @default.
- W2028595890 hasRelatedWork W1501966396 @default.
- W2028595890 hasRelatedWork W2014219907 @default.
- W2028595890 hasRelatedWork W2032417410 @default.
- W2028595890 hasRelatedWork W2037500960 @default.
- W2028595890 hasRelatedWork W2064238629 @default.
- W2028595890 hasRelatedWork W2114670571 @default.
- W2028595890 hasRelatedWork W2126517516 @default.
- W2028595890 hasRelatedWork W2142556013 @default.
- W2028595890 hasRelatedWork W2343857200 @default.
- W2028595890 hasRelatedWork W76598613 @default.
- W2028595890 hasVolume "31" @default.
- W2028595890 isParatext "false" @default.
- W2028595890 isRetracted "false" @default.
- W2028595890 magId "2028595890" @default.
- W2028595890 workType "article" @default.