FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028595898> ?p ?o ?g. }

• W2028595898 endingPage "106" @default.
• W2028595898 startingPage "99" @default.
• W2028595898 abstract "Paired-pulse depression was studied at the glutamatergic synapse between retinal afferents and thalamocortical cells in the rat dorsal lateral geniculate nucleus. The main objective of this study was to examine the contributions of the pre- and postsynaptic sites to this depression by comparing AMPA- and NMDA-receptor-mediated responses. Equal depression of the two receptor components would indicate involvement of presynaptic mechanisms, while differences in depression would indicate involvement of postsynaptic mechanisms. Pharmacologically isolated AMPA- and NMDA-receptor-mediated currents were recorded using the whole-cell patch-clamp technique in acute thalamic slices. Both the AMPA and the NMDA components showed pronounced depression when retinal afferents were activated by paired pulses. The depression decayed within 5 s. The AMPA component was more strongly depressed than the NMDA component at paired-pulse intervals ranging from 20 to 200 ms, suggesting the involvement of postsynaptic mechanisms. For intervals of 500 ms and longer, the depression of the two components was identical, suggesting the involvement of purely presynaptic mechanisms. The degree of depression measured without the use of pharmacological tools produced similar results, thus excluding the involvement of presynaptic ionotropic glutamate receptors. Cyclothiazide, a blocker of AMPA-receptor desensitisation, reduced the difference in depression between the two components, suggesting that desensitisation of the AMPA receptors is a postsynaptic mechanism that contributes to the difference in depression between the AMPA and the NMDA components." @default.
• W2028595898 created "2016-06-24" @default.
• W2028595898 creator A5012206941 @default.
• W2028595898 creator A5047491013 @default.
• W2028595898 date "2002-07-01" @default.
• W2028595898 modified "2023-10-16" @default.
• W2028595898 title "AMPA and NMDA currents show different short‐term depression in the dorsal lateral geniculate nucleus of the rat" @default.
• W2028595898 cites W1522787199 @default.
• W2028595898 cites W1571745125 @default.
• W2028595898 cites W1601000163 @default.
• W2028595898 cites W1636225847 @default.
• W2028595898 cites W1658264879 @default.
• W2028595898 cites W1748089690 @default.
• W2028595898 cites W1964694199 @default.
• W2028595898 cites W1965604491 @default.
• W2028595898 cites W1972883531 @default.
• W2028595898 cites W1976182199 @default.
• W2028595898 cites W1986615265 @default.
• W2028595898 cites W1986923087 @default.
• W2028595898 cites W1988900265 @default.
• W2028595898 cites W1989795714 @default.
• W2028595898 cites W1992613763 @default.
• W2028595898 cites W1997568797 @default.
• W2028595898 cites W1998347917 @default.
• W2028595898 cites W1999435938 @default.
• W2028595898 cites W2001520037 @default.
• W2028595898 cites W2001860569 @default.
• W2028595898 cites W2002426597 @default.
• W2028595898 cites W2021536670 @default.
• W2028595898 cites W2022995207 @default.
• W2028595898 cites W2025853041 @default.
• W2028595898 cites W2037772094 @default.
• W2028595898 cites W2038359286 @default.
• W2028595898 cites W2055320926 @default.
• W2028595898 cites W2063261415 @default.
• W2028595898 cites W2065069563 @default.
• W2028595898 cites W2066562577 @default.
• W2028595898 cites W2073577145 @default.
• W2028595898 cites W2076883859 @default.
• W2028595898 cites W2080778713 @default.
• W2028595898 cites W2084038314 @default.
• W2028595898 cites W2089178397 @default.
• W2028595898 cites W2089653659 @default.
• W2028595898 cites W2107490696 @default.
• W2028595898 cites W2116573581 @default.
• W2028595898 cites W2119885696 @default.
• W2028595898 cites W2121889340 @default.
• W2028595898 cites W2127660458 @default.
• W2028595898 cites W2128806021 @default.
• W2028595898 cites W2130926390 @default.
• W2028595898 cites W2135917845 @default.
• W2028595898 cites W2139384331 @default.
• W2028595898 cites W2149537605 @default.
• W2028595898 cites W2161729720 @default.
• W2028595898 cites W2162668311 @default.
• W2028595898 cites W2408910316 @default.
• W2028595898 cites W2460840553 @default.
• W2028595898 cites W3021526609 @default.
• W2028595898 cites W3166732914 @default.
• W2028595898 doi "https://doi.org/10.1113/jphysiol.2002.019240" @default.
• W2028595898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2290400" @default.
• W2028595898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12096054" @default.
• W2028595898 hasPublicationYear "2002" @default.
• W2028595898 type Work @default.
• W2028595898 sameAs 2028595898 @default.
• W2028595898 citedByCount "24" @default.
• W2028595898 countsByYear W20285958982012 @default.
• W2028595898 countsByYear W20285958982014 @default.
• W2028595898 countsByYear W20285958982016 @default.
• W2028595898 countsByYear W20285958982017 @default.
• W2028595898 countsByYear W20285958982018 @default.
• W2028595898 countsByYear W20285958982019 @default.
• W2028595898 countsByYear W20285958982020 @default.
• W2028595898 countsByYear W20285958982021 @default.
• W2028595898 countsByYear W20285958982022 @default.
• W2028595898 crossrefType "journal-article" @default.
• W2028595898 hasAuthorship W2028595898A5012206941 @default.
• W2028595898 hasAuthorship W2028595898A5047491013 @default.
• W2028595898 hasBestOaLocation W20285958982 @default.
• W2028595898 hasConcept C160268369 @default.
• W2028595898 hasConcept C169760540 @default.
• W2028595898 hasConcept C170493617 @default.
• W2028595898 hasConcept C185592680 @default.
• W2028595898 hasConcept C197341189 @default.
• W2028595898 hasConcept C55493867 @default.
• W2028595898 hasConcept C67018056 @default.
• W2028595898 hasConcept C73009533 @default.
• W2028595898 hasConcept C86803240 @default.
• W2028595898 hasConceptScore W2028595898C160268369 @default.
• W2028595898 hasConceptScore W2028595898C169760540 @default.
• W2028595898 hasConceptScore W2028595898C170493617 @default.
• W2028595898 hasConceptScore W2028595898C185592680 @default.
• W2028595898 hasConceptScore W2028595898C197341189 @default.
• W2028595898 hasConceptScore W2028595898C55493867 @default.
• W2028595898 hasConceptScore W2028595898C67018056 @default.
• W2028595898 hasConceptScore W2028595898C73009533 @default.
• W2028595898 hasConceptScore W2028595898C86803240 @default.
• W2028595898 hasIssue "1" @default.

• next