FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028597364> ?p ?o ?g. }

• W2028597364 endingPage "e1004413" @default.
• W2028597364 startingPage "e1004413" @default.
• W2028597364 abstract "Cohesins are important for chromosome structure and chromosome segregation during mitosis and meiosis. Cohesins are composed of two structural maintenance of chromosomes (SMC1-SMC3) proteins that form a V-shaped heterodimer structure, which is bridged by a α-kleisin protein and a stromal antigen (STAG) protein. Previous studies in mouse have shown that there is one SMC1 protein (SMC1β), two α-kleisins (RAD21L and REC8) and one STAG protein (STAG3) that are meiosis-specific. During meiosis, homologous chromosomes must recombine with one another in the context of a tripartite structure known as the synaptonemal complex (SC). From interaction studies, it has been shown that there are at least four meiosis-specific forms of cohesin, which together with the mitotic cohesin complex, are lateral components of the SC. STAG3 is the only meiosis-specific subunit that is represented within all four meiosis-specific cohesin complexes. In Stag3 mutant germ cells, the protein level of other meiosis-specific cohesin subunits (SMC1β, RAD21L and REC8) is reduced, and their localization to chromosome axes is disrupted. In contrast, the mitotic cohesin complex remains intact and localizes robustly to the meiotic chromosome axes. The instability of meiosis-specific cohesins observed in Stag3 mutants results in aberrant DNA repair processes, and disruption of synapsis between homologous chromosomes. Furthermore, mutation of Stag3 results in perturbation of pericentromeric heterochromatin clustering, and disruption of centromere cohesion between sister chromatids during meiotic prophase. These defects result in early prophase I arrest and apoptosis in both male and female germ cells. The meiotic defects observed in Stag3 mutants are more severe when compared to single mutants for Smc1β, Rec8 and Rad21l, however they are not as severe as the Rec8, Rad21l double mutants. Taken together, our study demonstrates that STAG3 is required for the stability of all meiosis-specific cohesin complexes. Furthermore, our data suggests that STAG3 is required for structural changes of chromosomes that mediate chromosome pairing and synapsis, DNA repair and progression of meiosis." @default.
• W2028597364 created "2016-06-24" @default.
• W2028597364 creator A5008092941 @default.
• W2028597364 creator A5024655738 @default.
• W2028597364 creator A5025389737 @default.
• W2028597364 creator A5034780971 @default.
• W2028597364 creator A5040829995 @default.
• W2028597364 creator A5046556617 @default.
• W2028597364 creator A5059281479 @default.
• W2028597364 creator A5066046575 @default.
• W2028597364 creator A5072545083 @default.
• W2028597364 date "2014-07-03" @default.
• W2028597364 modified "2023-09-26" @default.
• W2028597364 title "Meiosis-Specific Cohesin Component, Stag3 Is Essential for Maintaining Centromere Chromatid Cohesion, and Required for DNA Repair and Synapsis between Homologous Chromosomes" @default.
• W2028597364 cites W142190260 @default.
• W2028597364 cites W1530897177 @default.
• W2028597364 cites W1785184015 @default.
• W2028597364 cites W1794578906 @default.
• W2028597364 cites W1963766206 @default.
• W2028597364 cites W1963821249 @default.
• W2028597364 cites W1968777735 @default.
• W2028597364 cites W1970551701 @default.
• W2028597364 cites W1971771310 @default.
• W2028597364 cites W1976877135 @default.
• W2028597364 cites W1980639342 @default.
• W2028597364 cites W1986907906 @default.
• W2028597364 cites W1990850819 @default.
• W2028597364 cites W1999718358 @default.
• W2028597364 cites W2006301813 @default.
• W2028597364 cites W2007645732 @default.
• W2028597364 cites W2008553523 @default.
• W2028597364 cites W2016464119 @default.
• W2028597364 cites W2023411715 @default.
• W2028597364 cites W2026803831 @default.
• W2028597364 cites W2030222772 @default.
• W2028597364 cites W2031847595 @default.
• W2028597364 cites W2032267444 @default.
• W2028597364 cites W2032397353 @default.
• W2028597364 cites W2033082106 @default.
• W2028597364 cites W2042871902 @default.
• W2028597364 cites W2042969091 @default.
• W2028597364 cites W2043895957 @default.
• W2028597364 cites W2049901437 @default.
• W2028597364 cites W2062058774 @default.
• W2028597364 cites W2063017153 @default.
• W2028597364 cites W2063292930 @default.
• W2028597364 cites W2079163873 @default.
• W2028597364 cites W2080484525 @default.
• W2028597364 cites W2085544097 @default.
• W2028597364 cites W2092091855 @default.
• W2028597364 cites W2094892383 @default.
• W2028597364 cites W2095754453 @default.
• W2028597364 cites W2096338613 @default.
• W2028597364 cites W2096564869 @default.
• W2028597364 cites W2097891387 @default.
• W2028597364 cites W2109700294 @default.
• W2028597364 cites W2114485649 @default.
• W2028597364 cites W2118746619 @default.
• W2028597364 cites W2118972444 @default.
• W2028597364 cites W2120785595 @default.
• W2028597364 cites W2120918097 @default.
• W2028597364 cites W2122494067 @default.
• W2028597364 cites W2122880658 @default.
• W2028597364 cites W2125663691 @default.
• W2028597364 cites W2133894023 @default.
• W2028597364 cites W2137131184 @default.
• W2028597364 cites W2140074366 @default.
• W2028597364 cites W2140159026 @default.
• W2028597364 cites W2140451392 @default.
• W2028597364 cites W2144761938 @default.
• W2028597364 cites W2146848384 @default.
• W2028597364 cites W2147295960 @default.
• W2028597364 cites W2150566170 @default.
• W2028597364 cites W2150599578 @default.
• W2028597364 cites W2155324891 @default.
• W2028597364 cites W2156370264 @default.
• W2028597364 cites W2157166433 @default.
• W2028597364 cites W2159317724 @default.
• W2028597364 cites W2160352834 @default.
• W2028597364 cites W2169640319 @default.
• W2028597364 cites W2286297234 @default.
• W2028597364 doi "https://doi.org/10.1371/journal.pgen.1004413" @default.
• W2028597364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4081007" @default.
• W2028597364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24992337" @default.
• W2028597364 hasPublicationYear "2014" @default.
• W2028597364 type Work @default.
• W2028597364 sameAs 2028597364 @default.
• W2028597364 citedByCount "97" @default.
• W2028597364 countsByYear W20285973642014 @default.
• W2028597364 countsByYear W20285973642015 @default.
• W2028597364 countsByYear W20285973642016 @default.
• W2028597364 countsByYear W20285973642017 @default.
• W2028597364 countsByYear W20285973642018 @default.
• W2028597364 countsByYear W20285973642019 @default.
• W2028597364 countsByYear W20285973642020 @default.
• W2028597364 countsByYear W20285973642021 @default.
• W2028597364 countsByYear W20285973642022 @default.
• W2028597364 countsByYear W20285973642023 @default.

• next