FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2028603973> ?p ?o ?g. }

• W2028603973 endingPage "118" @default.
• W2028603973 startingPage "110" @default.
• W2028603973 abstract "The purpose of this study was to investigate the effect of PEGylation of novel biodegradable macromolecular polydisulfide Gd(III) complexes, gadolinium diethylenetriaminepentaacetate (GdDTPA) cystine copolymers (GDCP), on their pharmacokinetics and long-term Gd(III) tissue retention, and to demonstrate the potential application of PEGylated GDCP (PEG-GDCP) for MR angiography (MRA). The pharmacokinetics, biodistribution, and metabolic excretion of PEG(1000)-GDCP (42.1-52.1 kDa; PEG: MW = 1000 Da) with three different PEG grafting degrees and GDCP (43.3 kDa) were investigated in Sprague-Dawley rats. Pharmacokinetic data were analyzed by means of an open two-compartment model. Initially all three PEG(1000)-GDCP contrast agents (CAs) had a higher plasma concentration than GDCP, but after 30 min the Gd(III) concentration from the PEGylated agents rapidly decreased, resulting in significantly lower elimination half-life values. All of the biodegradable macromolecular CAs demonstrated low long-term Gd(III) tissue accumulation, while PEG(1000)-GDCP had significantly lower accumulation in the liver than GDCP. In the rats, all CAs showed excellent vascular contrast enhancement in an MRA protocol with a long image acquisition time. Because PEG(1000)-GDCP remained intravascular for an acceptable period for effective contrast-enhanced (CE)-MRA, and then excreted rapidly from the vasculature with minimal tissue retention, PEG(1000)-GDCP shows a great promise as a blood-pool CA for MRA." @default.
• W2028603973 created "2016-06-24" @default.
• W2028603973 creator A5012355912 @default.
• W2028603973 creator A5016856927 @default.
• W2028603973 creator A5020601619 @default.
• W2028603973 creator A5029421723 @default.
• W2028603973 creator A5049593207 @default.
• W2028603973 creator A5055819685 @default.
• W2028603973 creator A5069614464 @default.
• W2028603973 creator A5070372356 @default.
• W2028603973 date "2007-07-01" @default.
• W2028603973 modified "2023-09-26" @default.
• W2028603973 title "Modification of Gd‐DTPA cystine copolymers with PEG‐1000 optimizes pharmacokinetics and tissue retention for magnetic resonance angiography" @default.
• W2028603973 cites W1526755525 @default.
• W2028603973 cites W1673406890 @default.
• W2028603973 cites W1966283382 @default.
• W2028603973 cites W1976673956 @default.
• W2028603973 cites W1978673416 @default.
• W2028603973 cites W1982422473 @default.
• W2028603973 cites W1986410969 @default.
• W2028603973 cites W1988597642 @default.
• W2028603973 cites W1991895557 @default.
• W2028603973 cites W1992635038 @default.
• W2028603973 cites W1996713438 @default.
• W2028603973 cites W1998970140 @default.
• W2028603973 cites W2014342100 @default.
• W2028603973 cites W2014961437 @default.
• W2028603973 cites W2016617663 @default.
• W2028603973 cites W2021721463 @default.
• W2028603973 cites W2022309796 @default.
• W2028603973 cites W2023766552 @default.
• W2028603973 cites W2028784319 @default.
• W2028603973 cites W2035192326 @default.
• W2028603973 cites W2037283807 @default.
• W2028603973 cites W2052769484 @default.
• W2028603973 cites W2056291535 @default.
• W2028603973 cites W2059864970 @default.
• W2028603973 cites W2059938449 @default.
• W2028603973 cites W2060860123 @default.
• W2028603973 cites W2062509529 @default.
• W2028603973 cites W2071378710 @default.
• W2028603973 cites W2079582871 @default.
• W2028603973 cites W2088532287 @default.
• W2028603973 cites W2096435855 @default.
• W2028603973 cites W2162467938 @default.
• W2028603973 cites W2170111873 @default.
• W2028603973 cites W2327544948 @default.
• W2028603973 cites W2551598071 @default.
• W2028603973 doi "https://doi.org/10.1002/mrm.21270" @default.
• W2028603973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17659618" @default.
• W2028603973 hasPublicationYear "2007" @default.
• W2028603973 type Work @default.
• W2028603973 sameAs 2028603973 @default.
• W2028603973 citedByCount "15" @default.
• W2028603973 countsByYear W20286039732012 @default.
• W2028603973 countsByYear W20286039732013 @default.
• W2028603973 countsByYear W20286039732015 @default.
• W2028603973 countsByYear W20286039732018 @default.
• W2028603973 countsByYear W20286039732023 @default.
• W2028603973 crossrefType "journal-article" @default.
• W2028603973 hasAuthorship W2028603973A5012355912 @default.
• W2028603973 hasAuthorship W2028603973A5016856927 @default.
• W2028603973 hasAuthorship W2028603973A5020601619 @default.
• W2028603973 hasAuthorship W2028603973A5029421723 @default.
• W2028603973 hasAuthorship W2028603973A5049593207 @default.
• W2028603973 hasAuthorship W2028603973A5055819685 @default.
• W2028603973 hasAuthorship W2028603973A5069614464 @default.
• W2028603973 hasAuthorship W2028603973A5070372356 @default.
• W2028603973 hasConcept C10138342 @default.
• W2028603973 hasConcept C112705442 @default.
• W2028603973 hasConcept C126838900 @default.
• W2028603973 hasConcept C143409427 @default.
• W2028603973 hasConcept C162324750 @default.
• W2028603973 hasConcept C178790620 @default.
• W2028603973 hasConcept C185592680 @default.
• W2028603973 hasConcept C202751555 @default.
• W2028603973 hasConcept C2776964284 @default.
• W2028603973 hasConcept C2777807558 @default.
• W2028603973 hasConcept C2778978742 @default.
• W2028603973 hasConcept C2779149719 @default.
• W2028603973 hasConcept C54400483 @default.
• W2028603973 hasConcept C55493867 @default.
• W2028603973 hasConcept C557651011 @default.
• W2028603973 hasConcept C71924100 @default.
• W2028603973 hasConcept C98274493 @default.
• W2028603973 hasConceptScore W2028603973C10138342 @default.
• W2028603973 hasConceptScore W2028603973C112705442 @default.
• W2028603973 hasConceptScore W2028603973C126838900 @default.
• W2028603973 hasConceptScore W2028603973C143409427 @default.
• W2028603973 hasConceptScore W2028603973C162324750 @default.
• W2028603973 hasConceptScore W2028603973C178790620 @default.
• W2028603973 hasConceptScore W2028603973C185592680 @default.
• W2028603973 hasConceptScore W2028603973C202751555 @default.
• W2028603973 hasConceptScore W2028603973C2776964284 @default.
• W2028603973 hasConceptScore W2028603973C2777807558 @default.
• W2028603973 hasConceptScore W2028603973C2778978742 @default.
• W2028603973 hasConceptScore W2028603973C2779149719 @default.
• W2028603973 hasConceptScore W2028603973C54400483 @default.

• next