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- W2028609711 abstract "Provisional Advisory Levels (PALs) are concentrations in air and drinking water for priority toxic chemicals. This article summarizes the Standing Operating Procedure (SOP) currently in place for the data-driven development of chemical-specific PALs. To provide consistency and transparency, and to avoid faults of arbitrariness, the SOP was developed for guidance in deriving PAL values. Three levels (PAL 1, PAL 2, and PAL 3), distinguished by severity of toxic effects, are developed for 24-hour, 30-day, 90-day, and 2-year durations of potential drinking water and inhalation exposures for the general public. The SOP for PAL development focuses on (1) data acquisition and analysis, (2) identification of a chemical-specific critical effect, (3) selection of a quantitative point-of-departure (POD), (4) uncertainty analysis and adjustments, (5) exposure duration adjustment and extrapolation, (6) identification of special concerns and issues, and (7) verification, documentation, and dissemination of PALs. To avoid uncompromising rigidity in deriving PAL values and to allow for incorporation of new or refined methodologies, the overall procedure is fluid and subject to modification. The purpose of this publication is to provide a summary of this SOP." @default.
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- W2028609711 date "2009-10-14" @default.
- W2028609711 modified "2023-09-24" @default.
- W2028609711 title "Overview of the Standing Operating Procedure (SOP) for the development of Provisional Advisory Levels (PALs)" @default.
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- W2028609711 doi "https://doi.org/10.3109/08958370903202747" @default.
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