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- W2028609919 abstract "Gene and expression library immunization make it possible to functionally test all the gene-encoded antigens of a pathogen in a host challenge system. This comprehensive method could generate new and better vaccine candidates. We constructed expression libraries from simian immunodeficiency virus (SIV) cDNA and genetically immunize monkeys with the libraries alone or with a low dose of plasmids encoding human IL-12 and GMCSF. Eight of twelve animals in the three test groups showed some anti-SIV immune response, whereas the controls did not. Six months after priming, monkeys were intravenously challenged with virulent SIVmac251. All were infected but animals in two groups vaccinated with SIV libraries showed a trend toward lower viral-loads, mitigated clinical disease, and higher survival rates than controls. Significantly, co-administering the GMCSF and IL-12-encoding plasmids worsened these measures of protection. This preliminary study should encourage further development of library-vaccine strategies and caution the use of cytokines as adjuvants." @default.
- W2028609919 created "2016-06-24" @default.
- W2028609919 creator A5003748765 @default.
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- W2028609919 date "2002-05-01" @default.
- W2028609919 modified "2023-10-11" @default.
- W2028609919 title "Evaluation of SIV library vaccines with genetic cytokines in a macaque challenge" @default.
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- W2028609919 doi "https://doi.org/10.1016/s0264-410x(02)00094-4" @default.
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