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- W2028615037 abstract "Based on recent substrate specificity studies, a series of ribonucleotide based esters and carbamates were synthesized and screened as inhibitors of the phosphoramidases and acyl-AMP hydrolases, Escherichia coli Histidine Triad Nucleotide Binding Protein (ecHinT) and human Histidine Triad Nucleotide Binding Protein 1 (hHint1). Using our established phosphoramidase assay, K(i) values were determined. All compounds exhibited non-competitive inhibition profiles. The carbamate based inhibitors were shown to successfully suppress the Hint1-associated phenotype in E. coli, suggesting that they are permeable intracellular inhibitors of ecHinT." @default.
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- W2028615037 date "2012-01-01" @default.
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- W2028615037 title "Synthesis and evaluation of potential inhibitors of human and Escherichia coli histidine triad nucleotide binding proteins" @default.
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- W2028615037 doi "https://doi.org/10.1016/j.bmcl.2011.10.082" @default.
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