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- W2028617823 abstract "compared by likelihood ratio tests and Akaike's A Information Criterion. RESULTS: The random environmental and/or a multifactorial components were insufficient to fully explain the familial nature of FBE, but rather there is segregation of a major type transmitted from one generation to the next (p-value < 10-10). An incompletely dominant inheritance model together with a polygenic component fits the data best. For this dominant model, the estimated average penetrance of the dominant allele is 0.1005 (95% CI: 0.0587 to 0.1667) and the average sporadic rate is 0.0012 (95% confidence interval: 0.0004 to 0.0042), corresponding to an average relative risk of 82.53 (95% confidence interval: 28.70 to 237.35), or odds ratio of 91.63 (95% CI: 32.01 to 262.29). CONCLUSIONS: This segregation analysis provides epidemiological evidence in support of one or more rare autosomally inherited dominant susceptibility allele(s) in FBE families, and hence motivates linkage analyses." @default.
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- W2028617823 date "2010-05-01" @default.
- W2028617823 modified "2023-10-17" @default.
- W2028617823 title "17 Prior Endoscopy and Follow-up Strategies in Patients With High Grade Dysplasia in Barrett's Esophagus: A Dutch Population-Based Study" @default.
- W2028617823 doi "https://doi.org/10.1016/s0016-5085(10)60011-x" @default.
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